رسائل ماجيستير
English
2016
Screening of Lupus Anticoagulant in Women with Recurrent Miscarriage Attending Wad Medani Obstetrics and Gynecology Teaching Hospital Gezira State, Sudan
Zeinab Mohamed Modwy Fadl Alla, Albadawi Abdelbagi Talha
كلية علوم المختبرات الطبية-جامعة الجزيرة · السودان
Recurrent miscarriage (RM) defined as three or more consecutive pregnancy losses. It affectsabout 5-15% of all pregnancies worldwide .Recurrent miscarriage is a critical problem in which many factors play a crucial role such as Lupus anticoagulants (LA) which are Immunoglobulins usually IgG, IgM or both directed against plasma proteins such as prothrombin or annexin V that are bound to phospholipids. This study was aimed to screening of lupus anticoagulant in women with unexplained recurrent miscarriages in Wad Medani Teaching Hospital of Obstetrics and Gynecology also the study aimed to determine the association between age of women with recurrent miscarriage, number of miscarriage, and family history of recurrent miscarriage, pregnancy and age of fetal loss with positive cases of lupus anticoagulant (LA). This study was a descriptive cross sectional study conducted from January - April 2015. A total of 50 women with three or more recurrent miscarriage were screened for the presence of lupus anticoagulant (LA). The study was found the occurrence of lupus anticoagulant (LA) was 3/50 (6%) in women with recurrent unexplained miscarriage in Wad Medani Teaching Hospital of Obstetrics and Gynecology. The study was found that 1/50 (33.3%) of positive cases for (LA) in the age between (20 – 30), were pregnant and had three miscarriages, and (66.7%) of positive cases their age between (31- 40) years, were non pregnant and had six miscarriages. All positive cases 3/50 (100%) for lupus anticoagulant have a family history of recurrent miscarriage and their age of fetal loss between (1 – 13) weeks. The study was reported there was a statistical significant association between family history of recurrent miscarriage (p value=0.04), age of fetal loss (p value=0.03), and positively of lupus anticoagulant and there was no a statistical significant association between age of women with recurrent miscarriage, pregnancies, number of miscarriages and positively of lupus anticoagulant. the researcher recommended to do the screening of lupus anticoagulant as a part of routine investigation for women with unexplained recurrent miscarriage.