رسائل ماجيستير
English
2021
Study on Prothrombin Time International Normalize Ratio and Activated Partial Thromboplastin Time among Patients with Hypothyroidism National Cancer Institute University of Gezira Sudan 2020
Ahmed Hassan Ahmed, ALbadawi Abdelbagi Talha , Khalid Abdelsamea Mohamed Ahmed Abdella
كلية علوم المختبرات الطبية-جامعة الجزيرة · السودان
Hypothyroid modify physiological process of primary and secondary haemostasis and may lead to a higher bleeding risk. This is an analytical case control study aimed to study prothrombin time, international normalize ratio and activated partial throm boplastin time among patients with hypothyroidism and to compare results between healthy individual. The study conducted in the National Cancer Institute, during the period from January to October 2020. The study population were 50 patients with hypothyroidism, and 50 normal health individuals. A questionnaire was used to obtain patients’ information as age, gender, family history. The participants were orally interviewed after an informed verbal consent was taken. One point eight ml of venous blood was collected from all the participants in trisodium citrate container then centrifuged for 15 minute to obtain platelet poor plasma. Control M4 was used for measuring activated partial time and prothrombin time, data analysis by using SPSS program. The majority of participant in study group were female (82%) while male were (18%) and according to participant age 31-40 is most common age represent (36%), 30% of the participant have family history disease .The result showed activated partial thromboplastin time value significantly increased (P 0.000) in patients with hypothyroidism, while there no significant variation observed in the prothrombin time (P.value 0.849), and international normalize ratio (P. value 0.576) among the study population. According to severity of disease there were 43 (86%) of patients with mild hypothyroidism (Thyroid stimulating hormone ≤ 40mU/L), and 7 (14%) patients displaying severe hypothyroidism (Thyroid stimulating hormone > 40 m( . Activated partial thromboplastin time results were showed there were significant negative correlation with T4 and T3 level. While prothrombin time and international normalize ratio had no significant negative correlation, activated partial thromboplastin time results were showed there were significant positive correlation with Thyroid stimulating hormone level, while prothrombin time and international normalize ratio had no significant correlation. The study concluded that activated partial time was significantly increased to patient with hypothyroidism and recommended to evaluate routinely in patients with thyroid dysfunction.