عبدالله بن رفدان بن عبدالله الشهراني, محمد بن عمر بن سالم بازمول
كلية الدعوة وأصول الدين-جامعة أم القرى · السعودية
أسماء رضوان, وفاء جاسم محمود عابد
كلية الدراسات العليا-جامعة النجاح الوطنية · فلسطين
Background: In case of absent liquid dosage form, crushing a tablet or dispersing a capsule would be the most convenient option for using these drugs in patients with dysphagia difficulties. However, no bioequivalence or stability studies are conducted for these extemporaneous preparations, which leads to confusion regarding its efficacy and safety. In silico and in vitro tools have proven to be useful in predicting the in vivo performance of drugs depending on its physicochemical properties and it’s in vitro dissolution profiles. No liquid formulation of combination Amlodipine and Valsartan is available in the pharmaceutical market for use in pediatric population with hypertension.Purpose: The aim of the present study was to prepare an extemporaneous suspension of Amlodipine and Valsartan from available commercial tablets, and to evaluate the stability and dissolution properties of the compounded suspension.Method: Amlodipine/Valsartan extemporaneous suspension was prepared from available commercial tablets Valzadepine®. The dissolution profiles for the extemporaneous preparation and the commercial tablet was determined in different pH media. The physical, chemical and microbial stability of the compounded formulation was evaluated over one month period at room temperature. Moreover, In silico modeling using GastroPlus TM software was used to build absorption models for both drugs based on the in vitro dissolution data. The simulated plasma profile for both active ingredients were compared with the in vivo plasma profile to examine the similarity of the extemporaneous suspension and the commercial tablets.Results: The Amlodipine/Valsartan extemporaneous suspension was successfully prepared with acceptable organoleptic properties. The suspension was stable for four weeks period preserving its physical and chemical features. The release profiles of valsartan and Amlodepine from the suspension were similar to that from source tablet Valzadepine®. In silico modeling predicted similarity of the extemporaneous suspension and the commercial tablets.Conclusion: Amlodipine/Valsartan extemporaneous suspension could be prepared from available commercial tablets. Moreover, GastroPlusTM can be applied along with the in vitro dissolution in order to affirm similarity in extemporaneous compounding situations.
أحمد خضير عبيس الحميري, أشجان محمد عريبي الخالدي
كلية العلوم للبنات-جامعة بابل · العراق
A E A Dahou, Habbas houari, N L Meghoufel
كلية علوم الطبيعة والحياة-جامعة عبد الحميد بن باديس مستغانم · الجزائر
Jamal Ahmad , Fahad Almaskari , Kamran Khan, Yasser Jamal Eddin Aldaghestani
جامعة خليفة · الامارات
Over the past decade, friction stir welding of dissimilar materials has attracted substantial attention since it can be used in various industrial applications such as shipbuilding, aerospace, automotive and robotics, and most of these applications require light weight, cost effective, clean, and relatively safe components. In this study the joining of metal to polymer in a hybrid joint using friction stir lap welding was investigated. An experimental setup was built in order to test the feasibility of welding AA5052 to polypropylene (PP) in a lap joint. To begin with, multiple screening experiments were conducted to identify the working envelope. After that a full factorial design with three levels of each process parameter was performed. Forces in three directions (axial, welding, and lateral), joint lap shear strength, and the temperatures at the advancing and retreating side were analyzed by varying rotational speed, traverse speed, and tilt angle. Sound hybrid joint was achieved, and it was found that increasing the rotational speed and tilt angle resulted in an increase of the joint strength, while increasing the traverse speed lead to a decrease in the joint strength. Moreover, microstructure analysis was done by using scanning electron microscope (SEM) and revealed that mechanical interlocking induced by the generation of metal hooks contributed to the strength and performance of the joint. Direct relationship was found between hook size on the advancing side and lap shear strength. Also, elemental mapping at Al-PP interface was done and discovered the existence of magnesium, aluminum, carbon, and oxygen.
Cheikh Roumaissa Oueled, Fatma Zohra Haridi, Ibrahim Taleb, Radja Bouzit
كليات العلوم والتكنولوجيا-جامعة 8 ماي 1945 قالمة · الجزائر
بشار خــــــــــــــــالد علي, مهدي وهاب نعمة نصر الله
كلية الادارة والاقتصاد-جامعة كربلاء · العراق
حياة براهيمي, صبرينة بن مصر
كلية العلوم الاقتصادية والتجارية وعلوم التسيير-جامعة محمد البشير الإبراهيمي - برج بوعريريج · الجزائر
هدفت هذه الدراسة إلى بيان مدى مساهمة دراسة الجدوى المالية في اتخاذ القرار التمويلي، والوقوف على واقع إعداد وتطبيق دراسة الجدوى المالية على مستوى الوكالة الوطنية للدعم والتنمية المقاولاتية، ومن أجل ذلك تم الاعتماد على المنهج الوصفي في الجزء النظري لوصف البيانات والمعلومات، وتوضيح العلاقة بين مختلف المتغيرات وتحليل مختلف الجداول والأشكال والإحصائيات والنتائج، مع استخدام أداة جمع الوثائق والسجلات، من خلال تحليل دراسة المالية لأحد المشاريع الإستثمارية الصناعية التي قامت الوكالة بتمويله، توصلنا إلى عدة نتائج أهمها:•تعمل الوكالة على تقييم جدوى المشروع من خلال معيار صافي القيمة الحالية فقط؛•التدفقات النقدية الداخلة تغطي التدفقات النقدية الخارجة أي المشروع يحقق ربحية للمؤسسة؛•عدم وجود تعارض بين المؤشرات في عملية دراسة الجدوى المالية
Reeda Shawkat Harb, Tarek Nawas
مدرسة الآداب والعلوم-الجامعة اللبنانية الأميركية · لبنان
Farouk Benallel Boukhoulda , BOUKHOULDA, abdelaziz Encadreur: BOUKHOULDA, Farouk Benallel Coencadreur: Nouari, Mohammed, Mohammed Nouari
كلية التكنولوجيا-جامعة جيلالي ليابس – سيدي بلعباس · الجزائر
