Study of Macrophage Erythroblast Attacher Gene Polymorphism in Association with its Protein as an Index of Postmenopausal Osteoporosis
حسين علي حسين علوان , زينة عبد المنعم الجوادي , فاضل جواد ال طعمة
كلية الطب-جامعة كربلاء · العراق
0.05). There was no significant association between the investigation MAEA SNP rs10025665 and the risk of osteoporosis in the study population.\n Lower levels of serum MAEA protein in osteoporosis without (T2DM, and HTN) and High levels of enzyme bone alkaline phosphatase in postmenopausal women are associated with the development of-osteoporosis in Iraqi women.\n"}" data-sheets-user format="{"2":513,"3":{"1":0},"12":0}">Osteoporosis represents an increasing global health problem, with the highest incidence rates in postmenopausal women. Osteoporosis is a typical skeletal disorder described by low bone mass, which leads to reduced bone strength and an enhanced risk of fractures. The several genes involved in postmenopausal osteoporosis, Single Nucleotide Polymorphism rs10025665 in Macrophage Erythroblast Attacher gene (MAEA) has been suggested to be associated with osteoporosis. This study aims to investigate the association of MAEA gene polymorphism with postmenopausal osteoporosis women in Kerbala province and to determination the alkaline phosphatase isoenzyme in sera of osteoporosis and compare it with osteopenia group. The study design was a cross sectional study that included 160 women who were diagnosed by a physician and were divided into four groups: each group consisted of forty women as in the following: Postmenopausal Osteoporosis with type 2 diabetes mellitus(T2DM), postmenopausal Osteoporosis with hypertension (HTN), postmenopausal Osteoporosis without (diabetic Mellitus/hypertension) and postmenopausal osteopenia group. All groups of women were collected from the Al-Hassan center for Endocrinology and Osteoporosis Center at Al-Hussein Medical City in Kerbala City, for the period from November 2021 to March 2022.They were diagnosed with osteoporosis by measured T-score through DEXA scan at lumbar spine regions confirmed osteoporosis. Osteoporosis consisted of four categories that were collected at admission and the disease severity was assessed using WHO criteria. The patients were diagnosed previously with hypertension and patients with T2DM are based on physicians’ diagnosis before their current visit to the outpatient. The patients were diagnosed with osteoporosis when they first visited the Osteoporosis Center. The results of Vitamin D3 showed a significant difference that observed decreased Serum Vitamin D3 in all osteoporosis groups when compared with the osteopenia group(P<0.05). The results of Magnesium showed a significant decrease in all Osteoporosis groups compared to the osteopenia group (P<0.05).The results of the MAEA protein showed a significant decrease in osteoporosis without (T2DM, and HTN) when compared with osteopenia group (P.value<0.01), also showed a significant increase in osteoporosis with T2DM when compared with osteopenia group (P.value<0.01), while there is no significant difference between osteoporosis with HTN and osteopenia group. The results of bone alkaline phosphatase (BALP) showed a significant increase in osteoporosis and osteoporosis with hypertension when compared with the osteopenia group p.value<0.05 and nonsignificant in osteoporosis with T2DM.The genotypes of MAEA SNP rs10025665 were significantly associated with MAEA protein in (AA) and (AG) genotypes(p.value0.05). There was no significant association between the investigation MAEA SNP rs10025665 and the risk of osteoporosis in the study population. Lower levels of serum MAEA protein in osteoporosis without (T2DM, and HTN) and High levels of enzyme bone alkaline phosphatase in postmenopausal women are associated with the development of-osteoporosis in Iraqi women.