Ultrasound-Assisted Microwave Synthesis of Some Five and Six-Membered Heterocycles

الموضوعات

علوم بحتة وطبيعية

الملخص

Heterocyclic compounds containing nitrogen is the one of the most important biologicallyactive compounds. Their molecules incorporate the core structure of some antiviral,antibacterial, anticancer, antimalarial and antioxidant drug.In the present research work a series of five and six membered heterocycle containingnitrogen derived from chalcone were synthesized using sonochemistry and microwaveapproach as powerful tools for acceleration of both chalconization reaction and hetero-synthesis. These heterocycles include 2-amino 4,6-diaryl pyrimidine, 3,5-diaryl pyrazole, 3,5-diaryl isoxazole have synthesised from 1,3-diaryl-1,one-3-en. The enones were made in basiccondition and under sonication for 1 hour; this condition has given moderate to goodpercentage yield of 20-99.The synthesis of heterocycles was carried out using a combination of ultrasound andmicrowave irradiation. The reaction was performed using basic catalyst, and ethanolas solvent. A moderate to good yield have afforded in a period of time between 10-30minutes.This work describes a novel approach of combining ultrasound and microwaveirradiation in heterocyclization reactions to overcome solubility constraints and longreaction times.Furthermore, the mechanism of reaction has investigated by the isolation andcharacterization of two isoxazole intermediates, this investigation has demonstratedthat the products were formed through kinetic process.

روابط وملفات

التعريف والنوع

رقم الوثيقة

ffdf0125-a24d-470c-8099-f90c5bf3c860

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

36016_1.pdf, 36016_10.pdf, 36016_11.pdf, 36016_12.pdf, 36016_13.pdf, 36016_2.pdf, 36016_3.pdf, 36016_4.pdf, 36016_5.pdf, 36016_6.pdf, 36016_7.pdf, 36016_8.pdf, 36016_9.pdf

بيانات النشر

ترجمة العنوان

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ألقاب المؤلفين

[{"name_ar":"Ahmed Elsadig Mohammed Saeed","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Amin Osman Elzupir","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Izzeldeen Elfatih Barakat","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Ultrasound-Assisted Microwave Synthesis of Some Five and Six-Membered Heterocycles

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Ahmed Elsadig Mohammed Saeed, Izzeldeen Elfatih Barakat

الإعداد

Amin Osman Elzupir

الاقتباسات الببليوغرافية