إعداد وتحضير وتقييم النشاء العشبي كمادة مضافة للشكل الدوائي الصلب

الموضوعات

طب

الملخص

The objective of the study is to find a substitute for corn stch and find vious options for phmaceutical industry. Three types of grains were used which were “Hordeum vulge “Blay., Orchis mascula” Salep” pannistum americanum “ Pel millet” stch was extracted from the grains and their disintegration time was measured.-Physiochemical screing were used for determining the total value, moisture, protein, fat, fiber, pH, melting point, loss on drying, optical rotation, I.R, solubility, organoleptic evaluation, microbial contamination, swelling index, contt of cbohydrate.-Phmaceutical evaluation was used for determine bulk dsity, tapped dsity, average diameter and pticle size distribution, stch powder flow properties “angle repose, Hausner’s ratio and cs index.-The powder was transformed into granules with the usage of super disintegrant (poly vinyl pyrolidin P.V.P) for many conctrations, the phmaceutical evaluations above-mtioned were used to measure the disintegration time, and the best result was 7.5% of (P.V.P), this conctration was used in the other formulas. The objective of the study is to find a substitute for corn stch and find vious options for phmaceutical industry. Three types of grains were used which were “Hordeum vulge “Blay., Orchis mascula” Salep” pannistum americanum “ Pel millet” stch was extracted from the grains and their disintegration time was measured.-Physiochemical screing were used for determining the total value, moisture, protein, fat, fiber, pH, melting point, loss on drying, optical rotation, I.R, solubility, organoleptic evaluation, microbial contamination, swelling index, contt of cbohydrate.-Phmaceutical evaluation was used for determine bulk dsity, tapped dsity, average diameter and pticle size distribution, stch powder flow properties “angle repose, Hausner’s ratio and cs index.-The powder was transformed into granules with the usage of super disintegrant (poly vinyl pyrolidin P.V.P) for many conctrations, the phmaceutical evaluations above-mtioned were used to measure the disintegration time, and the best result was 7.5% of (P.V.P), this conctration was used in the other formulas. The granules were pressed into tablets by the usage of Apress of 15KN in order to determine the disintegration time. The granules were preped by wet and dry granulation techniques. The conctrations of the stch were (3%, 9%). Th they were evaluated by phmaceutical evaluations previously mtioned.-The granule was transformed into tablets weight viation, thickness, hdness and disintegration times were determined.-From the study results, we noticed that the results of the physiochemical screing e simil to the pameters of Syrian Arab Organization and Metrology. The results revealed the contamination of the stch because of its hygroscopic nature.-The results of the wet granulation method was better than dry granulation method and the results of phmaceutical evaluation were acceptable.-The sample with the lgest pticle size the shortest disintegration time, decrease the conctration of stch lead to rapid petration of water and an increase in disintegration time.The result of dissolution test was good within the limit of British phmacopeia.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0bfc6041-559a-456e-bfd9-c0a314c25d2d

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1643951_1.pdf

بيانات النشر

ألقاب المؤلفين

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اللغة

Arabic

المصدر والدورية

اسم المصدر

إعداد وتحضير وتقييم النشاء العشبي كمادة مضافة للشكل الدوائي الصلب

المحتوى والصفحات

عدد الصفحات

2

كلمات الباحثين

النشاء العشبي, شكل الدوائي الصلب

إشراف وإعداد

الإشراف

جمال صالح المزوغي, مصباح على الماجري

الإعداد

بثينة يوسف مهنى

الاقتباسات الببليوغرافية