يـاسـر العمـر , اسـامه محمد ديب الحنبظلي

كلية الطب البيطري-جامعة حماة · سوريا

ابتسام بوترعة, بشرى براهمية, سعودي كحول

كلية العلوم الإنسانية والاجتماعية-جامعة 8 ماي 1945 قالمة · الجزائر

غفران محمد مجيد, فراس عبدالله حسن

كلية العلوم-جامعة النهرين · العراق

Background: Hormone therapy is the first targeted therapy also called estrogen suppression therapy often used as an adjuvant therapy to reduce the risk of cancer back after surgery or cancer that has spread. Tamoxifen is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. It is used to reduce the risk of developing a more serious type of breast cancer in women. Present study was planned to assess the effect of tamoxifen on cytochrome P4502d6 enzyme activity. As well, study the cytotoxic effect of tamoxifen on MCF-7 breast cancer cell line and survey the apoptosis mechanism for MCF-7. Subjects and methods: This study includes (60) pre-menopausal women, their age ranged between (25-48) years. Thirty subjects were apparently healthy, chosen as control group (C group) and sixty patients with breast cancer (P group), were divided into two groups according to type of treatment: thirty five patients under tamoxifen treatment (P1 group), and twenty five patients under fluoxetine and tamoxifen treatment (P2 group). The levels of all parameters (age, weight, height, BMI, waist, hip, WHR) were quantitatively determined in patients and control. The second part of this study include the determination of the cytotoxic effects of tamoxifen against MCF7 breast cancer cell line and investigation of the mechanism by which the affected living cells toward apoptosis using Caspase -9 activity and High Content Screening (HCS) assay. II Results: Part I: A significant increase (p˂0.01) in the mean of BMI was observed in the (P1) group and (P2) group in comparison with that of the group (C) (30.3 and 32.1 vs. 25.18 Kg/m2 ). The mean level of serum cytochrome P450 2d6 has significant increase in group (P1) and group (P2) in comparison with that in group (C) (32.2 and 19.43 vs. 13.87 U/L) while the result showed a significant decrease in the group (P2) when compared with group (P1) Part II: Cytotoxic effects of tamoxifen against MCF-7 cell line showed half maximal inhibitory concentration IC50 value was at 4.506µg/ml which is the most significant cytotoxic toward MCF-7 cell line treated for 24 hours. The effect of the tamoxifen on the mechanism of apoptosis reveal a highly increased caspase-9 activity, which observed at 5 µg/ml concentration in MCF-7 cell, IC50 was at (4.506 µg/ml) The effect of the tamoxifen on the mechanism of apoptosis showed a significant increase with increased concentration (dose dependent) for cell membrane permeability, cytochrome c and nuclear intensity at (100µg/ml of tamoxifen) when compared with (20µg/ml) of doxorubicin as a standard. The effect of the tamoxifen on the mechanism of apoptosis showed a significant decrease when the concentration is increased (dose depended) for cell viability and mitochondrial membrane permeability at (100µg/ml) when compared with 20 µg/ml of doxorubicin as a positive control. III Conclusions: In patients treated with tamoxifen, the measurement of CYP2D6 activity showed a good indicator of breast cancer Tamoxifen possess cytotoxic effect against breast cancer cells (MCF-7), as determined in-vitro by MTT assay (4.506 µg/ml). A toxic effect of tamoxifen has been demonstrated on MCF-7 cell line by using caspase-9 at IC50 concentration (4.506 µg/ml) From HCS technique results; tamoxifen showed toxic effect toward MCF7 cell line at (100μg/ml) tamoxifen concentration in a dose-dependent manner with increase in cell membrane permeability, cytochrome C, nuclear intensity, and change in mitochondrial membrane potential and decrease in cell viability level

بن يحي الصديق, عثماني حسام الدين, قروف محمد كريم

كلية الاقتصاد والعلوم التجارية والإدارية-جامعة 8 ماي 1945 قالمة · الجزائر

يشتمل موضوع البحث على دراسة وتقييم فعالية نظام الرقابة الداخلية في البنوك، وقد تم التركيز ضمنه على دراسة حالةالصندوق الوطني للتوفير والاحتياط "بنك" بالجزائر، وذلك باعتبار أن البنوك تعد من أهم المؤسسات المالية التي تعملداخل النظام المصرفي، وهو ما يلزم بمتابعة ومراقبة أنشطتها بصرامة وفعالية لضمان استقرارها.وعلى هذا الأساس، فإنه تم دراسة وتحليل القواعد الأساسية في جانبها النظري والشاملة لمكونات نظام الرقابة الداخليةبالبنوك، بالإضافة الى دراسة فعاليته ضمن الحالة التطبيقية المتمثلة في الصندوق الوطني للتوفير والاحتياط مع تحديدمختلف الآليات والأساليب المستعملة في دراسة وتقييم مدى فعالية نظام الرقابة الداخلية بالبنوك.

حـاجــي فـاتــح, مريم قسمية

كلية العلوم الإنسانية والاجتماعية-جامعة جيلالي ليابس – سيدي بلعباس · الجزائر

خالد محمد طه محمود, محمد أحمد أبو النور

كلية الدراسات العليا والبحث العلمي-جامعة الرباط الوطني · السودان

The aim of this study is to describe the appearance of radial and ulnar arteries diameter by mean values and to determine the possible dominance arterial supply in radial or ulnar arteries. Know ledged the different diameters of forearm vessels is one of the most important factors in coronary bypass surgery and radial artery conduit. Methodology: 28 individuals (14 male, 14) females with mean age 30, 5 years ± 5, 5 selected systematically by systematic sample technique. Patient prepared for arterial evaluation by using color Doppler Ultrasound after 10 minutes rest on a couch. There was no hazard affecting the patients when using color Doppler ultrasound. All patients have informed consent for ethical clearance. Results: The mean diameter of right and left radial arteries was (2.5 ±.39) SD was (2.4 ±0.41) SD mm, (2.1 ± .29) SD mm respectively, and right, left ulnar arteries diameter was (2.4 ± .41) SD mm,( 2.2 ± .43) mm respectively. The dominant arterial supply was right radial artery. Discussion: There was no wide variation in mean diameter between radial and ulnar arteries in both hands due to most samples were for educated using their right hand rather than left. Subsequently, the dominant arterial supply of hand was right radial artery.

Cylia Kouk, Nassim Hamouraoui, Thinhinane Djerada

كلية العلوم الإنسانية والاجتماعية-جامعة عبد الرحمان ميرة - بجاية · الجزائر

Cette recherche exploratoire, qui porte sur les conceptions de la pensée critique dans le contexte de l'enseignement universitaire Alger ,Bejaia ,Sétif , tente de comprendre et de décrire la pensée critique telle qu'elle se présente (et non telle qu'elle devrait se présenter) par les enseignants universitaires. Ainsi, après avoir identifié les différentes conceptions de la nature de la pensée critique des enseignantes et des enseignants universitaires participants, nous tentons de les définir dans le contexte de l'enseignement universitaire Algérien. La démarche méthodologique utilisée est celle d'une recherche qualitative basée sur l'analyse du contenu. Cette recherche a été menée auprès de douze enseignantes et enseignants universitaires de l'Algérie intervenant dans différents domaines disciplinaires. Un questionnaire qualitatif qui comportait six questions a été utilisé comme outil de collecte des données. Ces questions ont permis d'identifier et décrire la définition de la pensée critique, ses caractéristiques et ses dimensions. Le codage et l'analyse des données se sont faits à partir d'un cadre de référence constitué préalablement par un ensemble varié des conceptions philosophiques, psychologiques et psychopédagogiques de la pensée critique. Les résultats de l'analyse révèlent cinq catégories de conceptions de la nature de la pensée critique (une pensée évaluative, une pensée raisonnable, une attitude critique, une activité mentale ou intellectuelle et une compétence professionnelle) et deux principaux rôles à la pensée critique (un rôle d'évaluation et un rôle d'approfondissement des connaissances)

السيد الألفي, صدام حسين محمد العزاني

كلية علوم وهندسة الحاسب الآلي-جامعة الملك فهد للبترول والمعادن · السعودية

With the exponential rise of online content and social media such as blogs, twitter and TV talks, analyzing this multimodal content to identify the attitude or opinions of persons on certain topics or products has gained growing importance in a wide variety of applications, ranging from customer service, political and social debates, to cybersecurity. Although a lot of work has been done for many languages to-date, especially English, not much has been done for the Arabic language. Moreover, it is expected that more effective sentiment and opinion analysis systems can be designed when combining different modalities of a person such as textual, audio and visual data. This study aims at exploring new approaches for automating multi-modal sentiment analysis and opinion mining for the Arabic language. We present a framework and develop a prototype that incorporates different modalities. The first multimodal sentiment analysis database for Arabic is built. Several architectures and fusion methods are evaluated and a new methodology is proposed.%This dissertation presents multimodal demographic characteristics to detect gender, age-group, dialect and nationality of user using audio, textual and visual modalities. The existing approaches are based on single modalities such as text, image, speech, or sequence of images (visual) individually.This dissertation presents a new direction of sentiment analysis to detect speakers' gender, age-group and dialects with their sentiments. The experimental results demonstrate that demographic characteristics as features are able to detect sentiment with an accuracy rate of 74.63%. Incorporating demographic features with textual, audio and visual modalities has led to improving the performance in nearly all cases with achieving an accuracy rate of 94.66%.%The research findings and outcomes, including the developed linguistic resources and tools, have been shared with the international research community, both for benchmarking, and further advancing this exciting multi-disciplinary field.

Fatima Zahra Elatiqi, محمد بوسكراوي

كلية الطب والصيدلة - مراكش-جامعة القاضي عياض · المغرب

أحمد بلخيري, علة مختار, علي عروي

كلية العلوم الاجتماعية والإنسانية-جامعة زيان عاشور - الجلفة · الجزائر