التقدير البيولوجي لجرعة تعرض مرضي سرطان الرئة المعالجين بالاشعة

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

fec17731-2fb0-4e83-ad75-a889f2fe3a1b

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1966440_1.pdf

بيانات النشر

ترجمة العنوان

Biological evaluation of exposure dose in lung cancer patient under going radiotherapy

ألقاب المؤلفين

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اللغة

Arabic

المصدر والدورية

اسم المصدر

التقدير البيولوجي لجرعة تعرض مرضي سرطان الرئة المعالجين بالاشعة

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

The purpose of this study is evaluation of exposure dose in lung cancer patients undergoing radiotherapy using biological methods ( micronuclies assay ) and comparing it with the dose evaluated by physical method. In order to reach this purpose we used cytokenesis-block micronuclies assay in peripheral blood lymphocytes and compared with controls for age, gender, smoking, and create dose-effect curves controls who don,t exposed to ionizing radiation . We collected blood samples from peripheral blood lymphocytes for lung cancer patients undergoing radiotherapy and that,s before and after radiotherapy and statistic micronuclies by microscope that,s for frequency study of micronuclies to this patients as biological methods to estimate chromosomal damage. And we collected blood samples from controls ( male and female ),and it exposure to different radiation doses of Gama rays by radiated this samples in vitro in calibration laboratory for frequency study of micronuclies and create dose-effect curves. In this study we evaluate chromosomal damage in peripheral blood lymphocytes for lung cancer patients and compared with it for controls. For this purpose we collected blood samples from controls and exposure it to radiation doses of Gama rays (0.2 - 0.5 - 1 - 2 Gy) and culture it for 72 hours for obtained to micronuclies, and we study this results by dose-effect curves. We collected blood samples from 25 lung cancer patients before and after radiotherapy, and culture it in same way, then we study frequency of micronuclies in this samples, and compared it with dose-effect curves. Our results in this study appear there is relation between micronuclies frequency and exposure dose increase, and we observed individual variations with rate of micronuclies in peripheral blood lymphocytes for male and female before and after radiotherapy. The results of this study indicate to individual variations for male and female before radiotherapy indicate to many effects such as smoking, chemotherapy, age, gender, etc. Individual variations for male and female after radiotherapy indicate to individual variation sensitivity in patients and specially after exposure to high doses and to age specially for female. 9 Our results don,t show an increase with micronuclies frequency for smokers compared with non- smokers. The average of micronuclies frequency in peripheral blood lymphocytes to males lung cancer patients before radiotherapy more than it,s for females lung cancer patients approximately (1.35). It was observed that the average of micronuclies frequency in peripheral blood lymphocytes to males lung cancer patients after radiotherapy more than it,s for females lung cancer patients. The average of micronuclies frequency in peripheral blood lymphocytes to lung cancer patients exposed to radiotherapy more than it,s in controls. Our results also showed that the average estimated radiation doses for patients with lung cancer were equivalent whole-body exposure to dose of6.8Gy., while the average dose of radiotherapy is 42.5 Gy. Which indicating the importance of micronucleus assay as a reliable method for estimation of total body doses resulting from the partial body exposure to ionizing radiation

كلمات الباحثين

التقدير البيولوجي, مرضي سرطان الرئة

إشراف وإعداد

الإشراف

عدنان اختيار, عصام قاسم

الإعداد

أمينة وليد خطاب

الاقتباسات الببليوغرافية