دراسة تأثير مستحضرات نباتية جديدة على بعض الكائنات الدقيقة المسببة للإنتانات الجلدية

الموضوعات

علوم بحتة وطبيعية

روابط وملفات

التعريف والنوع

رقم الوثيقة

fdfd14ea-765d-4a96-804d-50565ac5195c

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1965307_1.pdf

بيانات النشر

ترجمة العنوان

Testing the Antimicrobial Activity of New Herbal Dosage Forms Against Skin Infectious Microorganisms

ألقاب المؤلفين

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اللغة

Arabic

المصدر والدورية

اسم المصدر

دراسة تأثير مستحضرات نباتية جديدة على بعض الكائنات الدقيقة المسببة للإنتانات الجلدية

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

In this present study, antimicrobial potency and synergistic effect of hexanic and ethanolic extracts of Punica granatum fruit peel, Juglans regia leaves, Schinus molle leaves,Vitex agnus –castusfruit,Teucrium poliumaerial part,Melia azedarachleaves, Plantago lanceolataleaves against Staphylococcus aureusand candida albicans were investigated and compared. The antimicrobial activities of the extracts, individually and in combination were determined using agar diffusion method and the minimum inhibitory concentration (MIC) carried out by micro dilution method. Both the hexane and ethanol extracts of each plant material and mixture showed appreciable antimicrobial activities on S. aureusand C.albicans, antimicrobial activity increased with increasing concentration of the extracts, Individual activity of extracts tested of the plant parts(15-40mg/100μl) against the test organism ranged from 8.00±0.00 -23.00±1.00mm zone of growth inhibition and the synergistic activity of extracts tested of the plant parts, in various combinations against the test organism ranged from 11.333±1.155-20.333±0.557mm zone of growth inhibition. but the ethanol extract of Melia azedarach leaves (15,20mg/100μl), ethanol extract of Schinus molleleaves(15,20mg/100μl) and ethanol extract of Juglans regia(15mg/100μl) against S.aureuswas not activities . The antimicrobial efficacy of the mixture of extracts from plant parts increased considerably compared to the low activities recorded with the extract of individual plant parts. The minimum inhibitory concentration (MICs) of the individual plant parts ranged between 0.625 –5mg/100μl while the MICs of the combined extracts ranged between 0.0625-1.16 mg/100μl , the plant materials possessed antimicrobial activity with greater efficacy when used synergistically on the test organisms.. The individual and combined extracts activity compared favorably with the standard antibiotics of choice for therapy of skin infections that causing by Staph.aureus and C.albicans. The mixture of the extracts(hexanic extract of Vitex agnus–castusfruit,Teucrium poliumaerial part ,Melia azedarachleaves against S.aureus) and (ethanolic extract of Punica granatumfruit peel and hexanic extract of Vitex agnus–castusfruit ) was tested for treatment of the experimentally infected skin of Wister Albino Rate by C.albicans,Staph.aureus. The recovery period when using the mixture was 5-8 days in compared with 3-4 days for positive control (P<0.05) .This study showed that herbal extracts was tested and their mixture may be candidates for formulations that use to skin infection that caused by C.albicans and staph.aureus after doing more research.

كلمات الباحثين

, synergistic effect, Antimicrobial activity, Candida albicans skin infection, inhibition zone diameter, Staphylococcus aureus, الإنتانات الجلدية, التركيز المثبط الأصغرى, الفعالية المضادة للأحياء الدقيقة, المبيضات البيض, المكورات العنقودية الذهبية

إشراف وإعداد

الإشراف

ريم نيال, محمد ياسر عبجى

الإعداد

تسنيم الأحمد

الاقتباسات الببليوغرافية