Extraction, isolation and preliminary structural elucidation of some anti-cancer constituents of wild Urginea maritima and their antioxidant activities

الموضوعات

علوم تطبيقية وتكنولوجية

روابط وملفات

التعريف والنوع

رقم الوثيقة

fde76545-9a07-45d4-a469-8b8ad53f3f06

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1696509_1.pdf

بيانات النشر

ترجمة العنوان

الاستخلاص والتنقيه ومعرفة المركبات الاولية المضادة للسرطان من نبتة Urginea maritima البرية الفلسطينية وأنشطتها المضادة للأكسدة

ألقاب المؤلفين

[{"name_ar":"عائشة علي محمود ريان","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"فؤاد ريماوي","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Extraction, isolation and preliminary structural elucidation of some anti-cancer constituents of wild Urginea maritima and their antioxidant activities

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

For thousands ofyears, the holy land/Palestine, despite its small area, it contains colossal number of medicinal plants to which has been used as folkloric herbal medicine.Urginea maritima (U. maritima)is one of the medicinal plants that grows widely in Palestine. Samples of U. maritimawere collected from Abu-Dies region in January 2017, dried in shade for two weeks until it became completely dry, grinded, and then extracted by sonication. The aim of this research is to investigate the anticancerof flowers of U.maritimaon HCT116 and MDA (Colon and Breast cancer cells respectively), using solvents ofdifferent polarities(Distilled water, Ethanol, Ethyl acetate, Dichloromethane, and Hexane).Antioxidant activity(AA)was studied using differenttests like FRAP, DPPH, ABTS, and CUPRAC.Total phenolic content (TPC) and total flavonoids content (TFC) of the extracts was also conducted. Results showed thatethanolic extractof U.maritimahas higher anticancer activity compared to other solvents.Therefore,ethanolic extract was utilizedto HPLC-PDA analysis, semi-preparative HPLC-PDA fractionation and LCMS in both positive and negative ESi modes to elucidate some structures of the separated compounds. Allantioxidant activitytests (FRAP, DPPH, ABTS, CUPRAC), as well as TPC and TFC,was found to be higher for polar solvents like Distilled water, Ethanol, and Ethyl acetate, while it was found to be lower for non-polar solvents like dichloromethane and hexane. The inhibition of HCT-116 and MDA cancer cellswere found to be highwhen the concentration is 100g/ml, which was (50%after 24 hoursand 90% after 72hours for HCT 116 cells–90% after 24 hours and 100% after 72hours for MDA cells). Anticancer activity of U.maritimaextracts of 50g/ml was found to the similar to the concentration of 100g/ml, while (1, and 10)g/ml has very low activity.Which mean breast cancer cells have more efficacious as anticancer activity than colon cancer cells.

إشراف وإعداد

الإشراف

فؤاد ريماوي

الإعداد

عائشة علي محمود ريان

الاقتباسات الببليوغرافية