Determination of Antiphospholipid antibodies and Thrombophilia in women with Recurrent Miscarriage

الموضوعات

طب

الملخص

Recurrent miscarriage is a_critical problem in which many factors play a crucial role such asantiphospholipid antibodies (APA) and anticardiolipin antibodies (ACA).This study was a case control study, was conducted from Febraury-2008 to February -2011 in Khartoum State; it determined the haemostatic abnormalities and the frequency of theprimary and secondary antiphospholipid syndrome in women with history of recurrentmiscarriage (RM). A total of 100 women with three or more consecutive recurrent miscarriage ascase group and 100 non complicated pregnant women as control group were enrolled in thisstudy and were interviewed through clinically structured questionnaire to assess the risk factorsfor RM and an informed consent were obtained from them. Patient and control groups werescreened for the presence of antinuclear antibodies (ANA), anti-double stranded DNA (anti-dsDNA), antiphospholipid antibodies (APA IgM/IgG), and anticardiolipin antibodies (ACA/IgG)by using Enzyme linked Immuno-Sorbent assay (ELISA). The platelets were counted usingSysmex KXN-21. Activated Partial thromboplastin time (APTT), Prothrombin time (PT) andThrombin Time (TT) were measured using coagulometer biobas 10. Women positive for APAwere repeated the measuring of APA level after 6 as confirmatory test. All tests were analyzedusing Statistical Packages of Social Sciences Version 17 (SPSS program).Results showed that the frequencies for both APA and ACA were 20%, ANA and Anti-dsDNA were 12%, thrombocytopenia was 8%, LA was 20% , 5% had prolonged PT, where asthe remaining patient and control groups had normal results. There were a significant correlationbetween Age and the presence of APA (P=0.03), ACA (IgG) (P=0.04), ANA and Anti-dsDNA(P=0.0l3), LA (P=0.033) and thrombocytopenia (P=0.02), whereas PT had not influenced byage.The data concluded_ that the frequencies of APA, ACA, ANA, Anti-dsDNA, LA andthrombocytopenia in women with RM obtained in this study were in agreement to thefrequencies for these parameters obtained in previous studies and their presence weresignificantly associated with recurrent miscarriage.The current study recommends measuring of APA, ACA, Anti-dsDNA-antibodies, APTTand PT in all women with 3 or more consecutive pregnancy loss.

روابط وملفات

التعريف والنوع

رقم الوثيقة

fdd8cd19-482f-47ce-85e2-ecbfef984fce

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

63257_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"أحمد كامل بولاد","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"تقوى يوسف السيد يوسف","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Determination of Antiphospholipid antibodies and Thrombophilia in women with Recurrent Miscarriage

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

أحمد كامل بولاد

الإعداد

تقوى يوسف السيد يوسف

الاقتباسات الببليوغرافية