Microencapsulation of the Non-Steroidal Anti-Inflammatory Drugs into Biodegradable Polymers Using Supercritical Fluid Technology

الموضوعات

علوم تطبيقية وتكنولوجية

الملخص

Osteoarthritis is a disease that attacks human bones especially in older people and usually nonsteroidal anti-inflammatory drugs (NSAIDS) are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low aqueous solubility and in order to have their therapeutic effects, their solubility should be enhanced. The purpose of this study was to find solution for this problem and one way to do that is to reduce the particle size by forming micro particles. In this project, one of these types of drugs ibuprofen (isobutyl-propanoicphenolic Acid) was encapsulated into a polymer (PVP polyvinylpyrrolidone) using supercritical fluid technology (Supercritical CO 2 ) to form drug-polymer micro particles. Another aim was to measure the solubility, dissolution rate and surface characteristics of the prepared drug-polymer micro particles by characterizing them using various characterization techniques such as fourier transform infrared spectroscopy (FTIR) , ultraviolet spectroscopy (UV), transmission electron microscopy (TEM), scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Various drug-polymer formulations were prepared depending on various administrative dosages. Different conditions (i.e. different temperatures, pressures, flow rates and different drug solution: CO 2 volume ratio) were tested in preparing drug-polymer micro particles. Results from TEM images and FT -IR graphs show that micro particles were successfully prepared. Different conditions gave different shapes of drug-polymer micro particles in the SEM results. Finally, dissolution rate of the drug-polymer micro particles in the simulated gastric fluid showed promising results.

روابط وملفات

التعريف والنوع

رقم الوثيقة

fda66732-3c2a-452f-8e12-9b180645365f

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

8374_1.pdf

بيانات النشر

ترجمة العنوان

كبسلة البوليمرات القابلة للتحلل الحيوي بمضادات الالتهابات غير الستيرويدية باستخدام تقنية السائل فوق الحرج

ألقاب المؤلفين

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اللغة

English

المصدر والدورية

اسم المصدر

Microencapsulation of the Non-Steroidal Anti-Inflammatory Drugs into Biodegradable Polymers Using Supercritical Fluid Technology

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

علي المرزوقي

الإعداد

صفاء محمد المهدي علي يوسف

الاقتباسات الببليوغرافية