SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY

الموضوعات

طب

الملخص

Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. This study aims to conjugate CUR to succinic anhydride (SA) and then formulate in mannosylated-chitosan nanoparticles (CUR.SA-NPs). The formulation was optimized in comparison to curcumin only in the same delivery system. Dynamic light scattering (DLS) studies disclosed a higher size of CUR-NPs (268 ± 6 nm) and CUR.SA-NPs (342 ± 4.6 nm) compared to empty delivery system, CM-NPs, (101 ± 4.3 nm). Conversely, the zeta-potential was reduced from 41.2 ± 0.15 mV to 11 ± 0.75 mV and 13.6 ± 0.8 mV for CUR-NPs and CUR.SA-NPs respectively. The entrapment efficiency was 93.34 ± 0.40 for CUR-NPs, and 98.46 ± 0.06 for CUR.SA-NPs. Physical and structural characteristics of the formulated nanoparticles were investigated using FTIR, NMR, XRD, SEM, and TGA and each attest to the formation of the functionalized CUR.SA-CMNPs. In vitro drug release illustrated a sustained release profile of CUR and CUR.SA over a period of 3 days and an excellent cytotoxicity and intracellular uptake by CRC cell lines (SW480 and HCT116). Thus, CUR-NPs and CUR.SA-NPs can be considered as a promising delivery strategy for CRC treatment.

روابط وملفات

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التعريف والنوع

رقم الوثيقة: fd96e105-a8f0-4e27-bc48-d02e64711585
رقم العقد: 0
نوع الوسائط: Crawler
نوع المحتوى: الرسائل العلمية
صيغة المصدر: رسائل ماجيستير
نوع الملف: pdf text
أسماء الملفات: 798310_1.pdf

بيانات النشر

ألقاب المؤلفين: [{"name_ar":"Nashiru Billa","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Sourour Idoudi","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Yousef Hijji","title_ar":"اشراف","title_en":"Supervision"}]
اللغة: English

المصدر والدورية

اسم المصدر: SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY

المحتوى والصفحات

عدد الصفحات: 0
كلمات الباحثين: Curcumin Succinic Anhydride Mannose Chitosan Nanoparticles Ionic gelation Colorectal cancer

إشراف وإعداد

الإشراف: Nashiru Billa, Yousef Hijji
الإعداد: Sourour Idoudi

الاقتباسات الببليوغرافية

APA

Nashiru Billa،Sourour Idoudi و Yousef Hijji. (2022). SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY. أطروحة(رسائل ماجيستير). كلية الصيدلة-جامعة قطر. قطر.

MLA

Nashiru Billa،Sourour Idoudi و Yousef Hijji. SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY. 2022. كلية الصيدلة-جامعة قطر، رسائل ماجيستير.