Prevalence of Asymptomatic Carotid Artery Stenosis in Patients with Ischemic Heart Disease: A Systematic Review and Meta-analysis

الموضوعات

طب

الملخص

The coexistence of carotid artery disease in patients undergoing Coronary artery bypass graft (CABG) is a risk factor for stroke and death. Moreover,significant carotid artery disease in ischemic heart disease (IHD) patients increases the risk of developing peri-operative neurological events. For determining the value of screening in these high risk patients, reliable prevalence estimates are crucial. The aim of this systematic review and meta-analysis was to summarize the prevalence of asymptomatic carotid artery stenosis in patients with IHD at global, regional, andamong low, middle and high income countries.Objectives: The specific objectives of this study were to estimate the pooled prevalence of ACAS in IHD patients globally, regionally and country income group levels.Methods: In this systematic review and meta-analysis, EMBASE, Medline and CINAHL databases were searched from inception to June 2020. We included observational studies published in English reporting the prevalence of ACAS in IHD patients. Two reviewers independently assessed articles for inclusion, extracted data,and appraised the methodological quality of included studies. Statistical heterogene it was assessed by using the I² statistic and random effects models were employed inmeta-analysis to pool effect estimates.Results: Of 5486 articles identified, 51 were included in the systematic review and meta-analysis, with a total sample of 31,001 patients from five different regions. The pooled prevalence of ≥ 50% ACAS is 11% (95% CI 8-15%). The prevalence of ≥ 50%ACAS is 10% in American (AMR) region, 13% in both European (EUR) and Western pacific region (WPR), 9% in Eastern Mediterranean and 10% in South East Asian(SEAR) region. The pooled prevalence of ≥ 60% ACAS is 12% (95% CI 8-15%). The prevalence of ≥ 60% ACAS is 14%, 13% and 4% in AMR, EUR and EMR regions respectively. The pooled prevalence of ≥ 70% ACAS is 7% (95% CI 5-9%). According to the region, the prevalence of ≥ 70% ACAS is 7% in both AMR and EUR region, 4%in EMR and 6% in SEAR region. The pooled prevalence of ≥ 80% ACAS is 2% (95%CI 1-4%). Furthermore, the prevalence of ≥ 50% ACAS is 12% and 10% in high income(HIC) and low and middle income countries (LMIC). The prevalence is 13% and 8%in HIC and LMICs for ≥ 60% ACAS and 7% for both HIC and LMICs for ≥ 70%ACAS.Conclusion: This study suggested that the burden of ACAS in IHD patients remains substantial. The pooled prevalence of ACAS is variable among regions but overall the prevalence is higher in HICs compared to LMICs. Further longitudinal studies may provide information about the potential impact of screening for ACAS on morbidities and mortality in IHD patients.

روابط وملفات

التعريف والنوع

رقم الوثيقة

fcdaebce-fc21-4387-898e-d8dec4078af0

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2018079_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Mujahed Shraim","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Sadia Mahmood","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Prevalence of Asymptomatic Carotid Artery Stenosis in Patients with Ischemic Heart Disease: A Systematic Review and Meta-analysis

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Coronary artery bypass graft (CABG) - ischemic heart disease (IHD)

إشراف وإعداد

الإشراف

Mujahed Shraim

الإعداد

Sadia Mahmood

الاقتباسات الببليوغرافية