Immunohistochemical Expression of EGFR, Cytokeratin 5 and Cytokeratin 19 in Oral Squamous Cell Carcinoma and Adenocarcinoma in Sudanese Patients 2013 – 2015

الموضوعات

طب

الملخص

Oral cancers are considered as one the threatening cancers in Sudan due to their bad prognosis. The objective of this study was to investigate the expression of Epidermal Growth Factor Receptor (EGFR), Cytokeratin 5 and Cytokeratin 19 in squamous carcinoma and adenocarcinoma in Sudanese patients in Khartoum. 52 (27 males and 25 females) paraffin embedded cancerous oral tissue samples and 20 normal oral tissues were obtained from the histopathology laboratories of Khartoum teaching hospital, national health laboratory, Radiation and Isotope Center in Khartoum (RICK) and Khartoum dentistry hospital. However, the tissues were (1) Squamous cell carcinoma (47), (2) and Adenocarcinomas (5). This study was conducted after approval from the ethical committees of Gezira University and the Sudan ministry of health. Immunohistochemistry technique was used to determine the expression of the analyses. Regarding the results of EGFR staining 6 (12.7%) of the squamous carcinoma were negative while 41 (87%) were positive. The results of the cytokeratin 5 showed that half of the cancerous tissues were positive (25, 43.2%). 4 (8.6%) of the squamous carcinoma were positive for cytokeratin 19 and 45 (91.4%) were negative. 100% of adenocarcinoma EGFR positive, all CK5 adenocarcinoma patients were negative, and 60% of adenocarcinoma CK19 were positively. The staining of the normal tissues showed negative results for all the analyses. EGFR staining may be a promising marker which can be used as a target for oral cancers therapy. However, the Cytokeratins results illustrated the need for personalized oncology. EGFR recommended to be used in the diagnosis of squamous carcinoma and CK19 should not be used. In order to generalize the findings of this study it should be repeated in large scale and the diagnosis should be included by other techniques like Fluorescence In Situ Hybridization (FISH).

روابط وملفات

التعريف والنوع

رقم الوثيقة

fc7a75f1-8017-4a20-a6ea-5ab1087fb63e

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

73121_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Kannan Sanhouri ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":" Asim Awad Mohammed Ahmed","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Hussain GadElkarim Ahmed","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Immunohistochemical Expression of EGFR, Cytokeratin 5 and Cytokeratin 19 in Oral Squamous Cell Carcinoma and Adenocarcinoma in Sudanese Patients 2013 – 2015

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Kannan Sanhouri , Hussain GadElkarim Ahmed

الإعداد

Asim Awad Mohammed Ahmed

الاقتباسات الببليوغرافية