Evaluation of the physiological alterations and cardiotoxicity induced by doxorubicin chemotherapy in women cancer patients in El-Oued region and Study of the protective effect of Ocimum basilicum L. and MgNPs from these changes on Wistar rats

الموضوعات

علوم بحتة وطبيعية

الملخص

This investigation was aimed to determine the side effects of doxorubicin in cancer patientsand study the effect of leaves aqueous extract of Ocimum basilicum L. and magnesium oxidenanoparticles for prevention of cardiotoxicity and heart failure induced by doxorubicin in rats. Forpatient study, 22 women with cancer and control were chosen, blood samples were collected fromthem and some biochemical, enzymatic and hematological markers were measured. For in-vivorats study, twenty five female albino Wistar rats, weighing between 184.84 ± 8.48, were dividedinto 5 groups (n = 5); control group, doxorubicin treated rats group (Doxo), rats co-treated withdoxorubicin and aqueous extract of O. basilicum group ( Doxo + O. basilicum), rats co-treatedwith doxorubicin and magnesium nanoparticles group (Doxo + MgNPs) and rats co-treated withdoxorubicin, aqueous extract of O. basilicum and magnesium nanoparticles group (Doxo + O.basilicum + MgNPs). Doxorubicin induced cardiotoxicity using intraperitoneally single dose 1.5ml/kg/week. O. basilicum treated orally at a dose 200 mg/kg/day and MgNPs was supplementedintraperitoneally at one dose/week, 50 mg/kg for 4 weeks. Various hematological, biochemical,electrolyte, enzymatic, and oxidative stress markers were estimated. Histopathology of hearttissues was observed. Results of patients study show that doxorubicin induced change inbiochemical and enzymatic markers of heart function in women cancer patients compared towomen control. Results of in vitro phytochemical and HPL test results revealed that O. basilicumcontains most of active compounds, especially flavonoids of various kinds with high antioxidantactivity and without toxicity in rats. But, the MgNPs has a toxicity in rate up a dose (500mg/kg).Results of in-vivo rats study show that doxorubicin treated rats induced elevation in doxorubicinlevel in heart tissue, alteration in hematological and biochemical parameters compared to controlgroup. In addition, doxorubicin treated rats induced oxidative stress and histological alteration inheart cells compared to control rats. Co-treatment of doxorubicin with leaves aqueous extract ofO. basilicum and/or MgNPs were partially reversed all of previous parameters. This studyindicated that the anti-inflammatory and antioxidant property of leaves aqueous extract of O.basilicum and MgNPs allowed to use them to protect organs from the side effects of drugs or fromthe destructive effects of various diseases. Other studies are necessary to delve into these findingsand to determine the factors responsible for the beneficial effects.

روابط وملفات

التعريف والنوع

رقم الوثيقة

fb3012f2-1a19-4bfd-bda0-cd80ca3346a8

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

2038511_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Imane Yousra Boulaares","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Islam Guemari","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Samir Derouiche ","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

French

المصدر والدورية

اسم المصدر

Evaluation of the physiological alterations and cardiotoxicity induced by doxorubicin chemotherapy in women cancer patients in El-Oued region and Study of the protective effect of Ocimum basilicum L. and MgNPs from these changes on Wistar rats

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Samir Derouiche

الإعداد

Imane Yousra Boulaares, Islam Guemari

الاقتباسات الببليوغرافية