Inflammatory Bowel Disease in Sudanese Patients: A Pathological Study

الموضوعات

علوم بحتة وطبيعية

الملخص

Background and aims: Inflammatory bowel disease, a diseasepreviously thought to afflict predominantly people of western countries,has not gained the awareness and publicity among Sudanese cliniciansand pathologists. The aim of this study is to enlighten this dark area andprovide some epidemiologic, clinical and pathologic data oninflammatory bowel disease in Sudanese patients.Methods: Patients diagnosed with inflammatory bowel disease at SobaUniversity Hospital in the period 2006-2010 were retrospectively selectedfor the study. Clinical and endoscopic data were collected. Tissue blockswere retrieved and processed into H&E slides. The slides were reviewedand our observations compared to those on the original histopathologyreports. Any discrepancy between the two made the case excluded. Allthe data thus obtained was compiled into a checklist for each individualcase and analysed electronically.Results: Seventy two cases of inflammatory bowel disease were found inthe study period, 42 (58%) with ulcerative colitis, 15 (21%) with Crohn’sdisease and 15 (21%) with a label of indeterminate colitis. More caseswere diagnosed in the last three years of the study compared to the firsttwo. The age range was 14-87 years with the peak for ulcerative colitisVIIbetween 51-60 years and for Crohn’s disease between 31-40 years.Seventy two percent of the study population were males with a higherobserved prevalence among males for both ulcerative colitis and Crohn’sdisease. Seventy percent of the cases were from patients residing atcentral relatively more urbanised areas of the country. A third of the casesof Crohn’s disease were diagnosed from resection specimens compared tonone of ulcerative colitis cases. Granulomas were demonstrated in 60%of Crohn’s disease patients compared to only 2% of ulcerative colitiscases. Further, granulomas in Crohn’s disease patients were morefrequent in resection than in biopsy materials. Dysplasia was found in12.5% of the whole study population. Among patients with ulcerativecolitis and Crohn’s disease, dysplasia was found in 19% and 7%respectively. However, the association between frequency of dysplasiaand disease duration was difficult to estimate because of paucity of data.Conclusion: The number of new inflammatory bowel disease cases is onthe rise. A high volume of cases diagnosed as indeterminate colitis isnoted. Well designed epidemiologic studies are needed to verify theissues of disease locales and the relation of disease duration to thefrequency of dysplasia.

روابط وملفات

التعريف والنوع

رقم الوثيقة

f5537349-b35a-431e-b875-d2bac6e3f46b

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1638177_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"محمد محمد عثمان ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"معتز إبراهيم الصديق محمد نور","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Inflammatory Bowel Disease in Sudanese Patients: A Pathological Study

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

محمد محمد عثمان

الإعداد

معتز إبراهيم الصديق محمد نور

الاقتباسات الببليوغرافية