The Immuno-Pathogenesis of Severe Plasmodium falciparum Malaria in Sudanese Children

الموضوعات

علوم بحتة وطبيعية

الملخص

Malaria causes considerable morbidity and mortality among young children in malariaendemic areas worldwide. Anti-malarial antibodies are crucial determinants ofPlasmodium falciparum infection outcome. In this study the levels of circulatingimmunoglobulin-G antibodies specific to crude Plasmodium falciparum antigens weredetermined by an indirect enzyme-linked immunosorbent assay in a hospital based casecontrolstudy, of children with varying malaria severity living in the rural area of Gedarifeastern Sudan and El-Obied west of Sudan. The aims were to investigate ifimmunoglobulin-G subclasses correlated with the clinical presentation of the disease andother malariometric indices among children exposed to seasonal and unstablePlasmodium falciparum transmission. The levels of circulating interleukin-10 and thegenotypes of the single nucleotide polymorphism at position -1082 of IL-10 gene werealso investigated in relation to malaria severity.The results revealed that individuals with severe malaria had significantly lowerprevalence and levels of IgG1 and IgG4 as compared to those with uncomplicatedmalaria, suggesting a protective role for these molecules against severe malaria. Thelevels of IL-10 were lower in severe malaria patients as compared to those who presentedwith uncomplicated malaria, but no significant association was found between thespecific alleles or genotypes in the -1082 A/G polymorphic site and any particular formof clinical malaria.The present data argue for protective roles for IgG1 and IgG4 antibodies and IL-10against severe malaria, but find no evidence supporting significant effect of the differentalleles or genotypes at position (-1082A/G) of the IL-10 gene on protection from SM.

روابط وملفات

التعريف والنوع

رقم الوثيقة

f5259a7f-d6c9-49df-9687-5640bdc89c0f

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

1638519_1.pdf

بيانات النشر

ألقاب المؤلفين

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اللغة

English

المصدر والدورية

اسم المصدر

The Immuno-Pathogenesis of Severe Plasmodium falciparum Malaria in Sudanese Children

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

مصطفى إدريس البشير

الإعداد

عاطف حسان خير السعيد

الاقتباسات الببليوغرافية