Antitheilerial Activity of Some Medicinal Plants in Sudan

الموضوعات

طب

الملخص

This study investigates the antitheilerial activity (in vitro) of theaqueous extract of four local medicinal plants, Gardenia ternifolia(AbuGawie), Kigelia africana(Abu shutour), Sonchus cornutus(Moleita) andTinospora bakis(Irg al-Hagar). Preliminary screening of the aqueousextracts of the four plants foractivity against Theileria lestoquardi(ovine theileriosis) was done atconcentrations of 250, 500, 5000 and 10000 ppm. The antimalarial drug,Paluther (Artemether 80), was tested for antitheilerial effect. On the otherhand, Butalex (buparvaquone) was used as a standard drug. Screening for antitheilerial activity revealed K. africanato be themost potent candidate among the studied plants, followed by Gardeniaternifolia, and Tinospora bakis. However, Sonchus cornutuslacks activity.The highest activity of K. africana, Gardenia ternifolia andT. bakisat10000 ppm was 80%, 60% and 30%, respectively; Artemether 80producing 45% activity at 10mg/L. But buparvaquone at 10mg/L produced100% activity.LC50of K. africana, G. ternifolia andT. bakiswas 2660.28 ppm,6745.28ppm and 184268.54 ppm, respectively. However, Artemether 80and buparvaquone having LC50of 21.29 mg/L and 0.000015 mg/L,respectively. Plant extracts plus Artemether80 and buparvaquonecaused changesin the morphology, colour and mean number of macroschizonts. Thenumber of cells with extra cellular macroschizonts increased, but the meanXIVnumber of divided cells (binucleated and multinucleated) and viable cellsdecreased. The four plants, Artemether 80 and buparvaquone caused partialcytotoxicity at the highest concentration resulting in changes of themorphology of lymphoblast cells and decreasing the number of viablecells.

روابط وملفات

التعريف والنوع

رقم الوثيقة

f22cbbe2-04ca-45da-b3de-79233debb6bc

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf image

أسماء الملفات

f22cbbe2-04ca-45da-b3de-79233debb6bc_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Hayat Mahgoub Farah Mohammed","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Abdel Rahim Mohammed El Hussein","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Tigani Hassan Elamin","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Antitheilerial Activity of Some Medicinal Plants in Sudan

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Abdel Rahim Mohammed El Hussein, Tigani Hassan Elamin

الإعداد

Hayat Mahgoub Farah Mohammed

الاقتباسات الببليوغرافية