Aspect morphologique et évaluation de l’activité anti-inflammatoire de dattes (Phoenix dactylifera) variété Deglet Nour -Etude in vivo

الموضوعات

علوم بحتة وطبيعية

الملخص

Traditional medicine offers alternative remedies such as medicinal plants and natural products such asthe fruit of the date palm Phoenix dactylifera L. The dates contain bioactive compounds that give itinteresting biological virtues. It is in this context that we were interested in performing aphytochemical analysis of some secondary metabolites and in vivo anti-inflammatory activity of twoextracts of date palm fruit. the variety Deglet-Nour Algerian origin.In this work, two extracts were prepared from date fruit; aqueous and ketonic. Phytochemicalscreening of these extracts revealed several secondary metabolites, which probably give the date fruitits therapeutic properties elucidated by later work. This analysis was completed by a quantitativedetermination of total polyphenols and total flavonoids.The two studied date extracts are evaluated for their anti-inflammatory effects in vivo following the1% carrageenan-induced edema model at the subplantar portion of the paw of NMRI mice. The resultsof the percent inhibition of edema in mice treated with ketonic date extract at 200 mg / kg showed asignificant decrease in edema at the fourth hour (63,43%) and fifth (90,60%) compared to mice treatedwith Diclofenac (35,07% et 56,17%) respectively. Regarding the ketone extract, the three dosesadministered (100, 200 and 300 mg / kg) lead to inhibitions of edema at the third, fourth and fifthhours after the induction of inflammation at very close and significant percentages. compared to micetreated with Diclofenac.A histopathological study carried on the cutaneous tissue of the paw of the mice confirms the antiinflammatoryeffect of the two aqueous extracts and ketonic dates fruit. Thus presenting in micetreated with the two extracts studied a discrete inflammation with disseminated leucocyte infiltrate inthe dermis and blood capillaries of sizes close to normal compared to smiles treated with Diclofenacand untreated (positive controls). The latter revealed to the histology a very pronounced inflammationat the site of the lesion, which proves the inflammatory efficacy of carrageenan.Hence, this research finally allows us to affirm the anti-inflammatory effect of the two aqueous andketonic extracts of the date (Deglet-Nour) of Algerian origin, according to the conditions of ourexperimentation.

روابط وملفات

التعريف والنوع

رقم الوثيقة

f1fa224b-dc5f-4e68-8ba1-9e06e618ecc4

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

2055580_1.pdf

بيانات النشر

ألقاب المؤلفين

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اللغة

French

المصدر والدورية

اسم المصدر

Aspect morphologique et évaluation de l’activité anti-inflammatoire de dattes (Phoenix dactylifera) variété Deglet Nour -Etude in vivo

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Noureddine Djebli

الإعداد

Amina Djolti , Amira Kheira Souidi , Fatma Zohra Nesrine Baroudi

الاقتباسات الببليوغرافية