Cerebrospinal Fluid Biomarkers in Children with Acute Lymphoblastic Leukemia

الموضوعات

طب

الملخص

Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, and central nervous system (CNS) involvement represents a serious complication that adversely affects prognosis; however, conventional diagnostic approaches, particularly cerebrospinal fluid (CSF) cytology, have limited sensitivity and may fail to detect early leukemic infiltration, highlighting the need for more reliable biomarkers. This analytic cross-sectional study evaluated the diagnostic value of osteopontin (OPN) and soluble interleukin-2 receptor alpha (sIL-2Rα) in the CSF of 80 pediatric patients (1–17 years) with confirmed ALL enrolled between October 2024 and February 2025. CNS involvement was determined by cytospin CSF cytology, classifying patients as CSF-positive or CSF-negative, while CSF concentrations of OPN and sIL-2Rα were measured using sandwich ELISA. CNS infiltration was identified in 8.75% of patients, and both biomarkers were significantly elevated in the CSF-positive group compared with the CSF-negative group (p < 0.05). Moreover, a moderate positive correlation was observed between OPN and sIL-2Rα levels, and receiver operating characteristic analysis demonstrated good diagnostic accuracy for both markers in distinguishing CNS involvement. These findings indicate that elevated CSF levels of OPN and sIL-2Rα are strongly associated with CNS leukemia in pediatric ALL and suggest that these biomarkers may provide valuable diagnostic support, either individually or in combination, beyond conventional cytological methods.

روابط وملفات

التعريف والنوع

رقم الوثيقة

f07b81f0-15cc-4247-a67b-b8814dee6150

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1085453_1.pdf

بيانات النشر

ترجمة العنوان

المؤشرات الحيوية في السائل النخاعي الشوكي لدى الأطفال المصابين بسرطان الدم اللمفاوي الحاد

ألقاب المؤلفين

[{"name_ar":"رحيم مهدي رحيم","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"رويدة عايد صيهود إسماعيل","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"زياد طارق حبيب","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Cerebrospinal Fluid Biomarkers in Children with Acute Lymphoblastic Leukemia

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

رحيم مهدي رحيم, زياد طارق حبيب

الإعداد

رويدة عايد صيهود إسماعيل

الاقتباسات الببليوغرافية