التظاهرات السريرية والمخبرية للتلاسيميا ألفا في محافظة اللاذقية

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

f0207480-3787-43a9-9262-7a7c838b39d2

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1967257_1.pdf

بيانات النشر

ترجمة العنوان

Clinical and Laboratory Features of A-Thalassaemia in Lattakia City

ألقاب المؤلفين

[{"name_ar":"بانة ماهر عثمان","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"عطية خميس","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"ميخائيل جرجس","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

التظاهرات السريرية والمخبرية للتلاسيميا ألفا في محافظة اللاذقية

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

Aim oftheresearch. is to study the clinical and hematological characteristics of α-thalassemia specially hemoglobin H disease ,thus determine its features in our region to orient the type of genetic disorder. Furthermore,the goal of this study is to investigate the rate of occurrence of α-thalassemia in lattakia city by newborn screening to detect Hb Bart’s on cord blood, subsequently determination of silent carrier and α-thalassemia trait because of the difficulty to make known them after one month of age.Materials and methods.The medical records of 89 patients with hemoglobin H disease from Al-Assad hospital in Lattakia were reviewed to determine the clinical features by the story of disease.Hematological studies werealso made which involved : complete blood count, studying the red blood cell indices, electrophoresis on gel agarose in alkaline PH (PH=8,6) using Sebia device, BCB test to discover Hemoglobin H inclusion and some chemical tests (serum bilirubin, LDH, G6PD).Furthermore (303) cord blood samples were collected from pediatric interpolation hospital and Al-Assad hospital between 20/9/2011 to 26/2/2012. Automated blood count was made and also hemoglobin electrophoresis was made using electrophoresis device from Sebia in the medical Laboratory which belongs to Physician corporation in Lattakia city.Results.Although, hemoglobin H disease is common in Lattakia region, it’s diagnosed in older age because of low accuracy of hemoglobin electrophoresis in traditional laboratories. Furthermore, it’s misdiagnosed as iron deficiency anemia.This study reported that hemoglobin H. disease has moderate clinical and laboratory features which is relatively approach to deletional type ofα-genes in chinese research more thanpoint mutation which has more severe clinical and hematological forms.We also concluded that the average occurrence of α –thalassemia in newborn was 4%; 1% and 2,6% of them are silent carrier and α –thalassemia trait respectively. These cases are asymptomatic it’s difficult to diagnose it by traditional methods, furthermore it can causehemoglobin H disease or hydrops fetalis.

كلمات الباحثين

, hemoglobin H disease, alpha thalassemia, hemoglobin Bart's, اللتلاسيميا ألفا, الهيموغلوبين H

إشراف وإعداد

الإشراف

عطية خميس, ميخائيل جرجس

الإعداد

بانة ماهر عثمان

الاقتباسات الببليوغرافية