Rescue Of Embryonic Dysmorphogenesis in Diabetic Rats by Using the Antioxidant α- Lipoic Acid

الموضوعات

طب

الملخص

Background: The risk of congenital anomalies in children of diabetic mothers is three to four times that in offspring of non-diabetic mothers. The exact mechanisms of these birth defects are not known. Of the several factors suggested to contribute to embryonic maldevelopment in diabetic pregnancy, the formation of reactive oxygen species (ROS) and subsequent disturbances to cellar defenses appears to be a plausible hypothesis. Antioxidants have been reported to rescue the embryos from being malformed in animal experiments. This study was aimed to determine if the ideal antioxidant lipoic acid would ameliorate the embryos from maternal diabetes-induced anomalies. Methods: Female Wistar rats (200-250 gm) were assigned to five different treatment groups. Non-treated control rats, streptozotocin (STZ) (60 mg/kg)-induced diabetes mellitus, STZ diabetic rats treated with lipoic acid (STZ+LA), lipoic acid and Tris buffer treated rats (LA control), and Tris buffer alone treated rats. LA control and STZ+LA groups were treated with daily intraperitoneal injection of 20 mg/kg LA from GD 6 through GD 19. Morphological and skeletal malformations of the embryos were recorded. Results: Diabetic rats showed a significant incidence of resorption, growth retardation and malformation of fetuses. Lipoic acid and Tris buffer treatments showed no significant differences when compared with non-treated control data. Diabetic rats supplemented with lipoic acid had a significant decrease in fetal resorption/death, and improvement in fetal body weight. Lipoic also significantly reduced the incidence of various external and skeletal malformations in the diabetic group. Conclusion: Lipoic acid exerts a potent protective effect against diabetes-related resorption, intrauterine growth retardation and malformations. Prospective studies should aim at evaluating the exact mechanism by which LA acts to rescue embryos of growth retardation and malformations in this model.

روابط وملفات

التعريف والنوع

رقم الوثيقة

ee9b2922-2e19-49f7-b441-8f286d85661e

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

7765_1.pdf

بيانات النشر

ترجمة العنوان

تقليل التشوهات الجنينية في الفئران المصابة بالسكري باستخدام مضاد التأكسد الفا ايبويك اسيد

ألقاب المؤلفين

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اللغة

English

المصدر والدورية

اسم المصدر

Rescue Of Embryonic Dysmorphogenesis in Diabetic Rats by Using the Antioxidant α- Lipoic Acid

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

بريتل بيرج

الإعداد

مهيرة حمد ماجد رقيط الغفلي

الاقتباسات الببليوغرافية