Hypoglycemic medicinal plants used in Setif region and their effects on experimentally-induced diabetes in rats

الموضوعات

علوم تطبيقية وتكنولوجية

الملخص

The objective of this study is to evaluate the antioxidant and antidiabetic activity of Oleaeuropea, Trigonella foenum-graecum and Eucalyptus globulus extracts, which were popularthrough the survey, by Streptozotocin- induced diabetes in normal male adult rats viacomparison of changes in body weight, biochemical and histopatholoangical parameter.Intravenous injection of 50 mg/kg of Streptozotocin in rats, makes pancreas swell and causesdegeneration of beta cells in Langerhans islet and induces experimental diabetes in 2 days. Inthis study, the results showed that methanolic extract (ME) and chloroformic extract (ChE) ofEucalyptus globulus leaves contained high polyphenolics and flavonoids contents, respectively,whereas ethyl acetate extract (EAE) of Olea europea leaves and Trigonelle foenum-graecumseeds contain the most important quantity in polyphenols and flavonoids. The obtained resultsfrom HPLC technique allowed the detection of 36 phenolic compounds in MEO, 16 in METand 40 in MEE. In addition, ME of E.globulus showed a strong ABTS radical scavengingactivity, and inhibited the linoleic acid oxidation in ferric thiocyanate method and TBA. While,the EAE of O.europea and T.foenum-graecum exhibited a good activity in reducing power,ABTS and TBA assays. After Induction of diabetes, the volume of urine and glucose increasedin the untreated animals in comparison with normal ones, but the body weight decreased in theuntreated animals. The administration of MEO and MET at doses of 200 and 600 mg/kg andMEE at doses of 150 and 500mg/kg increased catalase activity, GSH level and decreased lipidperoxidation in the tissues of liver and kidneys, serum total cholesterol and triglycerides levels.Furthermore, histological damages in pancreas, kidney and liver tissues were reduced. Theseresults indicated a good hypoglycemic and antioxidant activity of the three studied plants, couldexplain their use in folk medicine in the control of diabetes and preventing diabeticcomplications by scavenging free radicals

روابط وملفات

التعريف والنوع

رقم الوثيقة

ee729bc2-1da3-4dd2-8f23-ec6dbc467ee3

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

2074097_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Dalila Bencheikh","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Seddik Khennouf","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Seraiche s. Dahamna","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

French

المصدر والدورية

اسم المصدر

Hypoglycemic medicinal plants used in Setif region and their effects on experimentally-induced diabetes in rats

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Seddik Khennouf, Seraiche s. Dahamna

الإعداد

Dalila Bencheikh

الاقتباسات الببليوغرافية