Evaluation de l’activité cicatrisante et de la toxicité aigue de l’extrait aqueux de l’Atriplex halimus chez le rat wistar

الموضوعات

علوم بحتة وطبيعية

الملخص

روابط وملفات

التعريف والنوع

رقم الوثيقة

eddfbd11-a6dc-4274-b6f6-fdaf5b31979a

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

2145818_1.pdf

بيانات النشر

ألقاب المؤلفين

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اللغة

French

المصدر والدورية

اسم المصدر

Evaluation de l’activité cicatrisante et de la toxicité aigue de l’extrait aqueux de l’Atriplex halimus chez le rat wistar

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

In this study, aqueous extract from the leaves of Atriplex halimus was studied for acute toxicityand healing activity in Wistar rats. For the study of acute toxicity, the extract was administeredin a dose of 5g / kg in unique dose, per Os to Wistar rats. The rats were monitored for 48 hours.The LD50 was over 5mg/kg. In the excision wound model, rats were classified into 4 groups offive rats each. Lot 1 served as a control, lot 2 received a standard treatment (MADECASSOLointment) and Lot 3 treated with cream base only (exipient) while Lot 4 was treated with acream based on Atriplex halimus leaf extract at a dose of 5% (study group). Healing activity wasevaluated by estimating the reduction in the surface area of the wound, the time required forcomplete epithelialization, and the resistance to skin rupture. The histological study of thegranulation tissue was performed to determine the extent of collagen formation in the woundtissue. In the excision wound, animals treated with Atriplex halimus cream showed a significantreduction (P < 0.001) in the area of the wound and a faster rate of epithelialization compared tocontrols. In addition, histological studies showed significantly higher activity in the 2 groupstreated with plant-based cream and MADECASSOL compared to the other groups. Our studyfound that the Atriplex-based preparation has a powerful healing activity.

كلمات الباحثين

healing activity, Atriplex halimus, acute toxicity, leaf, wounds

إشراف وإعداد

الإشراف

فتيحة ميسون

الإعداد

نزيهة الاهوايل, يمينة منصورية بن ياشو

الاقتباسات الببليوغرافية