Evaluation of toxicological and other properties of Sudanese rhanterium epapposum (ALRFAJ) And trichodesma africanun (Elhiraisha)

الموضوعات

علوم بحتة وطبيعية

الملخص

A concise information on the various active constituents of medicinal / poisonous plantswith particular emphasis on the toxicity of pyrrolizidine alkaloids to humans, livestockand laboratory animals was presented.Rhanrerium epapposum or Trichodesma africanum aerial parts were fed to rats at2,5,l0,and 20% of the standard diet for 12 weeks. Incorporation of Trichodesmaafiicanum aerial parts in diet at 20% was lethal to Wistar rats 6-7 weeks alter treatmentand caused severe hepatonephrotoxicity. Feeding 20% Rhanterium epappasum aerialparts for 12 weeks was not fatal and caused impaired growth and hepatonephrotoxicity.These changes were correlated with alterations in hematology and clinical chemistry.Damage to vital organs of rats fed 5% or 10% mixture of two plants was less intense,haematological and serobiochemical values were improved and growth was particularlypromoted by feeding 10% mixture of two plants.The comparative effects on rats of the aqueous and methanolic extracts of aerial partsof both plants given at different dose levels (300 and 75 mg/kg /day) and by differentroutes of administration ( oral or i.m) were investigated. Extracts of both plants weretoxic and fatal to rats at 300 mg/kg/day by whatever route it was given. Thecharacteristic features of extracts from both plants were hepatonephrotoxicity,leukocytosis due to lymphocytosis, macrocytic normochromic anaemia as well assevere haemorrhagic myositis at site of injection of the methanol extract particularlyfrom Trichadesma afiicanum aerial parts. These changes were evidenced byalterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT)and alkaline phosphatase(ALP) activity and total protein, albumin, globulin, cholesteroland urea concentrations. Bilirubin concentration did not change.The occurrence of splenic haemosiderosis might have been caused by saponins presentin the extract of T richodesma africanum aerial parts.The phytochemical screening of aerial parts of both plants was described .In vitro antibacterial activities of petroleum ether, methanol and water extracts fromaerial parts of Rh. epappasum and T africanum used in different concentrationslO,50,l00,2000 and l000ug/ml against Gram +ve bacteria (Bacillus sz/blilis andStaphylococcus aureus) and Gram -ve bacteria (Escherichia coll’, Klebsiella spp,Proteus vulgaris and Pseudomonas aeruginosa) were estimated.VIII

روابط وملفات

التعريف والنوع

رقم الوثيقة

ed60b14f-5e10-4a48-96df-88e04a26c0a5

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

63234_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"S. El Adam","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Shama Ibrahim Younis Adam","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Evaluation of toxicological and other properties of Sudanese rhanterium epapposum (ALRFAJ) And trichodesma africanun (Elhiraisha)

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

S. El Adam

الإعداد

Shama Ibrahim Younis Adam

الاقتباسات الببليوغرافية