ROLE OF CHRONIC CADMIUM EXPOSURE ON ADIPOSE TISSUE FUNCTION

الموضوعات

علوم بيئية

الملخص

Cadmium (Cd) is a toxic environmental pollutant with a bioaccumulation feature that exceeds 35 years without a known biological role in the living systems. Recently, Cd was found to be accumulated in adipose tissue (AT) which is known for its vital role in energy homeostasis and endocrine functions. The main goal of this study is to investigate the effect of low-dose chronic exposure of Cd on the function of AT in different locations. Sprague-Dawley male rats were exposed to low Cd dose (15 ppm) for ten weeks, then subcutaneous AT, abdominal AT, and retroperitoneal AT were extracted for molecular analysis. Adiponectin and leptin expression levels were evaluated to assess AT function, and Monocyte Chemoattractant Protein-1(MCP-1) was evaluated to assess the adipose tissue macrophages function. Our results showed significant downregulation of adiponectin and leptin mRNA expression in SUB-AT compared to other depots. Also, MCP-1 mRNA and the protein expression levels were downregulated in SUB-AT. These results suggest that chronic exposure to low-dose Cd disrupts the function of WAT in a depot-specific manner by altering the expression profile of the adipocytokines.

روابط وملفات

التعريف والنوع

رقم الوثيقة

ed26486e-b1b6-4225-99a2-ddd9a584e88c

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

798299_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Hamda A. Al Naemi","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Sarra Mohammed Attia","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

ROLE OF CHRONIC CADMIUM EXPOSURE ON ADIPOSE TISSUE FUNCTION

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Cadmium (Cd) adipose tissue (AT)

إشراف وإعداد

الإشراف

Hamda A. Al Naemi

الإعداد

Sarra Mohammed Attia

الاقتباسات الببليوغرافية