Effect of Heat, Sun light and Acidity on Metronidazole and Metronidazole Benzoate Using UV Spectroscopy

الموضوعات

علوم بحتة وطبيعية

الملخص

Metronidazole and Metronidazole Benzoate are antiamoebic, antiprotozoal , antibacterial, antiparasitic and antitrichomonal agents. The aim of this work is to study the effect of heat, sun light and pH on Metronidazole and Metronidazole Benzoate. The samples were donated by Amipharma laboratory,Khartoum. Different samples of drugs were exposed to different conditions (direct sun light, room temperature, refrigerator 80 C, oven 400 C and acidic medium) for different times. Two samples of drugs were exposed to sunlight, one protected for light and another not protected; to see the effect of light and heat together and effect of heat alone. Various samples were left at room temperature, fridged at 80 C, heated in an oven at 40 0C for three hours and dissolved in solution of hydrochloric acid at concentrations (1×10-5, 1×10-4, 5×10-4, 1×10-3, 5×10-3, 1×10-2, 5×10-2, 1×10-1 and 5×10-1)M. The samples were then analysed by UV spectrophotometry at wave length 320nm. It was found that the percentage of concentration of metronidazole after exposing to sun light for 3 hours was (93.45 and 52.71)% for protected for light and not protected one respectively, the percentage of concentration of metronidazole after left for 3 hours at room temperature, fridged at 80 C, heated in an oven at 400 C were (101.12, 102.24 and 99.81)% respectively, the percentage of concentration of metronidazole after dissolved in hydrochloric acid solution at concentrations (1×10-5, 1×10-4, 5×10-4, 1×10-3, 5×10-3, 1×10-2, 5×10-2, 1×10-1 and 5×10-1)M were (55.88, 54.95, 53.08, 51.40, 38.31, 30.09, 12.52, 10.46 and 6.91)% respectively, decreased with increased acid concentration. The results obtained that the Metronidazole and Metronidazole Benzoate samples are drastically affected by direct sun light indicating that the molecule becomes more susceptible to sunlight. But are stable at different temperatures. The results also showed that the degradation had increased when increasing concentration of acid, this indicates the instability in acidic medium. The study revealed that Metronidazole and Metronidazole Benzoate are largely affected by direct sunlight and unstable in acidic solutions. The study also explained the comparison between Metronidazole and Metronidazole Benzoate and the results indicate that Metronidazole Benzoate is more sensitive to sunlight and more unstable in acidic solution than Metronidazole. Therefore it is recommended that Metronidazole and Metronidazole Benzoate should be protected from light and it is recommended that further studies should be done on the stability of Metronidazole and Metronidazole Benzoa

روابط وملفات

التعريف والنوع

رقم الوثيقة

100ed8a1-86c1-4163-98cf-8ac1206b4926

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

73072_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"صالح محمد أحمد أبكر","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"فاطمه محمد احمد بابكر عبيد","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"فتح الرحمن عباس الشيخ","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Effect of Heat, Sun light and Acidity on Metronidazole and Metronidazole Benzoate Using UV Spectroscopy

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

صالح محمد أحمد أبكر, فتح الرحمن عباس الشيخ

الإعداد

فاطمه محمد احمد بابكر عبيد

الاقتباسات الببليوغرافية