Evaluation of Immune Response of Selected Sudanese Population To A and C Meningococcal Polysaccharide Vaccine During Meningitis Epidemic in Sudan

الموضوعات

طب

الملخص

The present study was carried out in greater Khartoum the capital of the Sudan. Thestudy was undertaken during group A meningococcal epidemic 1999.This study evaluated the immune response ofselected Sudanese population to A andC meningococcal polysaccharide vaccine during serogroup A meningococcalepidemic in Sudan, and compared the immune response of Sudanese adults and NorthAmerican adults to the unconjugate meningococcal polysaccharide vaccines.Convenient blood samples were collected from one hundred thirty seven healthySudanese individuals pre-immune ,10 days, one month, and one year after vaccinationwith A+C meningococcal polysaccharide vaccine in the period between May 1999and June 2000Serum samples collected from healthy American adults pre-vaccination and onemonth after vaccination with A, C, Y, W135 polysaccharide vaccine were stored at -80 Cº used in this study. The sera wereinvestigated using different laboratorymethods to measure the concentrations of antibody level and antibody activity,including Radio Antigen Binding Assay (RABA), Enzyme Linked Immuno SorbentAssay (ELISA), and Bactericidal assay.Serum group A anticapsular antibody concentrations measured by RABA hadstatistically significant difference, from the pre-immunization and 30 days postimmunization sera for the different Sudanese age groups (P 10 years for the Sudanese subjects showed the same correlation(R2=0.75, R2=0.69, R2=0.79, R2=0.69).Before immunization, , serum group A anticapsular antibody concentrations were 10-fold higher in adults, and 4-fold higher in the youngest and teenagers age group fromthe Sudan than adults from North American (geometric means of 29 µg/ml and 13µg/ml, respectively, vs. 3 µg/ml, P1:128). Nearly all Sudanesewith low antibody levels developed protective bactericidal antibody responses aftervaccination, and the magnitude of the anticapsular antibody responses of the Sudanesewas similar to that of the immunized North Americans,The high levels of naturally-acquired antibody in the Sudanese may reflectwidespread exposure to group A N. meningitidisduring the epidemic and due todifficulties of instituting immunization before exposure occurs

روابط وملفات

التعريف والنوع

رقم الوثيقة

0f3f7ea4-70da-4f01-81ff-d39cfe5a51b7

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

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أسماء الملفات

0f3f7ea4-70da-4f01-81ff-d39cfe5a51b7_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Adil Ahmed Ismail Ishag ","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Evaluation of Immune Response of Selected Sudanese Population To A and C Meningococcal Polysaccharide Vaccine During Meningitis Epidemic in Sudan

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإعداد

Adil Ahmed Ismail Ishag

الاقتباسات الببليوغرافية