دراسة التأثير الخافض لسكر الدم لنباتي القندريس و الأخيليا الناميين في سوريا عند جرذان مستحدثة الداء السكري

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

0e7dc7ab-3c84-483c-8a45-f20cc5a6f098

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1961620_1.pdf

بيانات النشر

ترجمة العنوان

Hypoglycemic Effect Evaluation of Onopordon heteracanthum and Achillea biebersteinii Afan Growing in Syria in Induced Diabetic Rats

ألقاب المؤلفين

[{"name_ar":" وسيم عبد الواحد ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":" ريم نيال","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"أحمد كرزون ","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

دراسة التأثير الخافض لسكر الدم لنباتي القندريس و الأخيليا الناميين في سوريا عند جرذان مستحدثة الداء السكري

المحتوى والصفحات

عدد الصفحات

157

ترجمة الملخص

Background and Objective: Supported by many studies and botanical surveys, the potential role of medicinal plants as antidiabetic agents has dramatically raised. The present study was designed to investigate the hypoglycemic effect of A. biebersteinii Afan. hydro-ethanolic extract and O. heteracanthum hydro-ethanolic extract.Materials and Methods: The study was designed to to investigate the hypoglycemic effect of A. biebersteinii Afan. hydro-ethanolic extract and O. heteracanthum hydro-ethanolic extract in both types of diabetes, using blood glucose and insulin levels as markers for their efficacy, morphological changes of pancreatic β-cell islets as a potential marker for a protective role, and high fat diet-streptozotocin (HFD-STZ) induced diabetic rats and STZ-induced diabetic rats as diabetic models.Aerial part hydro-ethanolic extracts of A. biebersteinii Afan. and aerial part hydro-ethanolic extracts ofO. heteracanthum were administered by oral gavage for 16 days at a dose of 400 mg/kg and 800 mg/kg,respectively. Glibenclamide at a dose of 3 mg/kg, and metformin at a dose of 300 mg/kg were used as reference standards. Results: A. biebersteinii Afan. reduced significantly blood glucose levels, improved oral glucose tolerance, tended to raise serum insulin levels, enhanced regeneration of βcells, increased size of the pancreatic islets and seemed to be more effective than the reference standards. It is assumed that A. biebersteinii Afan. increases utilization of glucose by tissues and/or enhances release of insulin from remanent and/or regenerated β-cells. O. heteracanthumworsened blood glucose levels within 60 minutes after administration in both types of diabetes, and did not have significant effect in type I diabetes. O. heteracanthum reduced FBG levels significantly in type II diabetes, improved significantly OGT, and didn’t seem to enhance regeneration of βcells. Conclusion:In conclusion, A. biebersteinii Afan. possesses potent antihyper glycemic activity and it may prove to be effective for the treatment of both types of diabetes. O. heteracanthum possesses extra pancreatic antihyper glycemic activity related to type II diabetes and prandial state.

إشراف وإعداد

الإشراف

وسيم عبد الواحد , ريم نيال

الإعداد

أحمد كرزون

الاقتباسات الببليوغرافية