اصطناع مشتقات إسترية لبعض الحموض الدوائية ودراسة بعض خصائصها

الموضوعات

علوم بحتة وطبيعية

روابط وملفات

التعريف والنوع

رقم الوثيقة

0e518a0b-e556-41c6-b955-b8d8159eda80

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1959068_1.pdf

بيانات النشر

ترجمة العنوان

Synthesis of Esters Derivatives of some Medical Acids and Studying some its Properties

ألقاب المؤلفين

[{"name_ar":"جمعة مرزا","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"محمد درويش عرابي","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"وردة خليل","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

اصطناع مشتقات إسترية لبعض الحموض الدوائية ودراسة بعض خصائصها

المحتوى والصفحات

عدد الصفحات

102

ترجمة الملخص

This research included the synthesis of four organic compounds starting from butan-1,3-diol and propan-1,2-diol with Pharmaceutical carboxylic acids by using Fischer Esterification Reaction to obtain mono esters these compounds are:1-2-hydroxypropyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl)acetate.2-3-hydroxybutyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl)acetate.3-2-hydroxypropyl 2-(3-benzoylphenyl)propanoate.4-3-hydroxybutyl 2-(3-benzoylphenyl)propanoate.First, the synthesis of indomethacin mono-ester by propylene glycol esterification with indomethacin acid was performed as a "model" reaction to study the optimal conditions for optimal yield of the best selectivity of the product.These were as following:1-Studying the effect the using of acidic homogeneous catalysts such as "Sulfuric Acid, Methane Sulfonic Acid" and heterogeneous acidic catalyst ecofriendly environmental as: "Amberlyst-15", heterogeneous catalyst "Amberlyst-15" was found to be the best catalyst compared to other catalysts used. 2-Studying the use of differet organic solvents in the Esterification Reaction such as: "Toluene, Dimethyl sulfoxyd" and compared these results with using of an exess of propan-1,2-diol solvent and as interaction compound. 1013-The optimal molar ratio of alcohol used as a reactant and as a solvent with carboxylic acid was determined to show the optimal ratio (8: 1)4-The optimal reaction time for the esterification of alcohol with indomethacin acid was studied using different “homogeneous and heterogeneous” acid catalysts showing that the best time was five hours.The preceding conditions of application of "heterogeneous acid catalyst Amberlyst-15, reaction time of 5 hours, temperature 110 ° C, alcohol content ofacid (1: 8)" were applied to different derivatives of pharmaceutical acids including indomethacin and ketoprofen.Finally, the application of optimal conditions in the preparation of mono esters of drugs for different lengths with different pharmacological acids.The biological activity of compounds manufactured against some germs and some fungi was studied and the results were compared with the effectiveness of the original pharmaceutical compounds. These were as following:1-Antibacterial activity,in particular HBK at 0.001 g / l, and inhalation diameter was 22 mm.2-Antifungal effectiveness.The molecular structures for all the obtained compounds have been determinate by spectroscopy methods: infrared spectroscopy FT-IR, nuclear magnetic resonance proton and carbon 1H, 13C-NMR, and suitable mechanisms to synthesize were proposed.

إشراف وإعداد

الإشراف

جمعة مرزا, وردة خليل

الإعداد

محمد درويش عرابي

الاقتباسات الببليوغرافية