Characterization Of Genomic Alterations And Tcrβ Repertoire Of Tumor- Infiltrating Lymphocytes In Breast Cancer

الموضوعات

طب

الملخص

Breast cancer still remains a major cause of morbidity and mortality amongwomen in Qatar and worldwide. More recent studies indicate that the diversity andthe composition of the entire set of antigen receptors within tumor-infiltratinglymphocytes (TILs) is strongly correlated with tumor prognosis and therapeuticresponse with breast cancer. Unfortunately, the relationship between somaticmutational load and TCR diversity of TILs across breast cancer still limited. Forthis purpose, first we characterized the somatic mutations of Formalin-FixedParaffin-Embedded breast cancer samples from 79 patients using NGS of a panelof cancer related genes. Second, we classified and identified the TCRß repertoirefor these 11 samples using the ImmunoSEQ platform. Preliminary datademonstrated that the 11 patients had high diversity of TCRß-CDR3 within thetumors. However, there was no statistically significant association between thesomatic mutational loads in the gene panels we sequenced and the number ofproductive TCRß-CDR3 rearrangements.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0db5a64b-7dbd-4b96-be3d-512e8d93d280

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

889523_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Ahmed Mohamed Malki Mohamed Youssef","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":" Ayeda Abdulsalam Ahmed","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Characterization Of Genomic Alterations And Tcrβ Repertoire Of Tumor- Infiltrating Lymphocytes In Breast Cancer

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Ahmed Mohamed Malki Mohamed Youssef

الإعداد

Ayeda Abdulsalam Ahmed

الاقتباسات الببليوغرافية