اختبار وظائف الصفيحات عند المرضى السكريين المصابين بالداء الشرياني الإكليلي والمعالجين بالكلوبيدوغريل

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

0d8909a0-188b-47f0-a5c3-463647e671a2

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1966990_1.pdf

بيانات النشر

ترجمة العنوان

Platelet Function Test in Diabetic Patients with Coronary Artery Disease on Clopidogrel Treatment

ألقاب المؤلفين

[{"name_ar":" محمود ملحيس","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"عبيدة العثمان","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

اختبار وظائف الصفيحات عند المرضى السكريين المصابين بالداء الشرياني الإكليلي والمعالجين بالكلوبيدوغريل

المحتوى والصفحات

عدد الصفحات

105

ترجمة الملخص

Aim: To assess platelet function profiles in diabetic and nondiabetic patients with coronary heart disease on combined aspirin and clopidogrel therapy.Methods and Materials:164 patients with stable coronary artery disease (randomly selectedfrom the patients who were referredto Aleppo University Heart Hospital from 1-3-2012 to 1-2-2013).To investigate platelet function in diabetic compared with nondiabetic patients already on aspirin treatment we study:1) the long-term effects of the maintenance dose of clopidogrel (75 mg) (group 1=75 mg Group, n 102) and2) the acute effects of a 300-mg clopidogrel loading dose (group 2= 300 mg Group, n62) Patients were stratified according to the presence of type 2 diabetes.Blood Samples were drawn 2-4 h after aspirin and clopidogrel intake in 75group and 24h after 300 mg clopidogrel intake in 300group.Platelet aggregation was assessedbyusing Multiple Electrode Aggregometry (MEA) after adding 20 mc.mol/l ADP to whole blood samples. The responsiveness to clopidogrel was assessed by using Area Under the Curve (AUC) which represents to the aggregation over the time [AU*min or U (10 AU*min = 1 U)]. We depend on AUC > or = 45 to define low-responders to clopidogrel.Results:None of the following (Age, Gender, Hypertension, Smoking, Family History, Platelet Count and Mean Platelet Volume) had a significant association with response to clopidogrel. But DM, Glucose level and A1C were independent predictivefactors to the response to clopidogrel.Diabetic subjects had a higher number of clopidogrel non-responders to either maintenance dose (75 mg) or loading dose (300 mg).Platelet aggregation was significantly increased in diabetic (in both groups) compared with nondiabetic (P < 0.05) There is a significant correlation between the high levels of plasmaglucose and the increased platelet aggregation (the high glucose the more aggregation).Glucose level (in groups 1 and 2) was significantly increased in low-responders compared with responders (P < 0.05).Poor control of glycemia is more frequently seen in diabetic low-responders to clopidogrel comparedwith those diabetic responders.In both groups: A1C was significantly increased in low-responders compared with responders (P < 0.05) Conclusion:There is a significant correlation between the presence of DM,the high levels ofplasmaglucose and poor control of glycemia, and the increased platelet aggregation after 75 mg or 300 mg clopidogrel intake in patients withstable coronary artery disease.

إشراف وإعداد

الإشراف

محمود ملحيس

الإعداد

عبيدة العثمان

الاقتباسات الببليوغرافية