Improvement of radiotherapy theoretically by nano–molecules as radiosensitive agent

الموضوعات

علوم تطبيقية وتكنولوجية

الملخص

This research includes a theoretical study to enhance radiotherapy using nanoparticles as a radiation-sensitive agent. Different structures of the Alpha-D-glucose molecule (α‐D‐glucose–C6H12O6) were used after its adsorption on the silver nanoparticles surfaces C6H12O6Ag3 and C12H24O12Ag. The properties of these configurations were evaluated using density functional theory (DFT) with a hybrid B3LYP function (Becke, three-parameters, Lee-Yang-Parr) and with 6‐311+G* as a basis set for C, O, and H atoms. However, for silver (Ag) atoms the basis was LANL2DZ used.The electronic properties and structure were studied by performing geometric optimization and obtaining the best configurations for the Alpha-D-glucose structures with silver nanoparticle’s by obtaining the stability energies for C6H12O6Ag3, C12H24O12Ag, and C6H12O6. Their values are – 687.140, – 1520.447, – 1124.712 respectively in Hatree units. The optimized structures were obtained by calculating the lengths of the bonds, bond angles and dihedral angles were also calculated, the electronic properties were studied, including the electronic energies, the distribution of electronic charges, and the energy gap for each compound, Vibrational modes were calculated for each compound.On the other hand, FTIR spectra were analyzed and studied, where it was found that there is agreement between the theoretical and practical studies after studying the properties with stability of these molecules. They were used with high-energy photons resulting from linear accelerators or from radioactive sources.The purpose of using these molecules is to increase the absorbed dose of radiation within infected cells in human organs (lungs). The goal of this reaction is to increase the cross-sectional area of interaction within the tumor by alpha–D glucose with silver nanoparticles in order to increase the absorbed dose within the tumor without damaging the healthy cells surrounding the tumor .XIII These molecules interacted with high energies of X-ray Radiation with a range of 2-15 MeV, the sensitivity to radiation (SER) is theoretically C6H12O6Ag3 compound E=2Mev, E=4Mev, E=6MeV equal13.86 while E=8 MeV,E=10 MeV equal14.75 ,E=12 Mev equal 13.95, ,E=14 Mev equal 14.84. At the maximum energy value of 15 MeV, equal 15.64 while C12H24O12Ag. E=2MeV equal 13.7, E=4MeV, E=6MeV, E=8MeV and E=10MeV equal 12.9, E=12MeV equal 12.5, E=14MeV equal 12.8. At the maximum energy value of 15 MeV, equal 12.9These values of radiation sensitivity resulted in a reduction of the number of radiotherapy sessions by approximately half the duration of treatment time.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0d3cabb5-a38c-4e30-8b56-f457f85d3aa7

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2280426_1.pdf

بيانات النشر

ترجمة العنوان

تحسين العلاج الاشعاعي نظريا بواسطة جزيئات النانو كعامل حساس للإشعاع

ألقاب المؤلفين

[{"name_ar":"نغم محي التميمي ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"ولاء شعلان سرحان عبد ","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Improvement of radiotherapy theoretically by nano–molecules as radiosensitive agent

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

radiotherapy theoretically

إشراف وإعداد

الإشراف

نغم محي التميمي

الإعداد

ولاء شعلان سرحان عبد

الاقتباسات الببليوغرافية