تحضير وتشخيص بعض المركبات الجديدة من مشتق البريميدين ودراسة الفعالية البايلوجية لها

الموضوعات

علوم بحتة وطبيعية

روابط وملفات

التعريف والنوع

رقم الوثيقة

0ce9fc76-b29e-4155-b404-30dac227cf9b

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2324992_1.pdf

بيانات النشر

ترجمة العنوان

Synthesis and identification of some new compounds from pyrimidine derivatives and study their biological activity

ألقاب المؤلفين

[{"name_ar":" حسين عـواد دلي","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"شيماء عدنان بهجت","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

تحضير وتشخيص بعض المركبات الجديدة من مشتق البريميدين ودراسة الفعالية البايلوجية لها

المحتوى والصفحات

عدد الصفحات

11

ترجمة الملخص

This study included synthesis of heterocyclic compounds derivatives such as : (oxazepine , imidazolidine , beta-lactam , tetrazol , thiazolidine ) . All chemical reactions to preparation of the compounds under study were investigated by using TLC technique, The physical properties of the prepared compounds were also studied . These compounds were Identification by infrared spectroscopy (FT-IR) and (1H-NMR) and (13C-NMR) . After diagnosis of spectra compounds their biological effect was studied on two types of bacteria: Staphylococcus aureuses (Gram positive) and Escherichia coli (Gram Negative) the causes of many common diseases, and the compounds were found to have different biological some of them show inhiation (biological activity) and other were not. The selection of compound of more biological activity and studies its effect onHep2 cancer cell . This work is divided in to two parts :- Part one :- The first step includes preparation of first Schiff base derivative (compound 1) from reaction 2-amino-4-hydroxy-6methyl pyrimidine with 3-amino acetophenone in acid medium while second step includes synthesis of di Schiff base derivative (compound 2) from reaction compound (1) with 4-hydroxy acetophenone , the third step includes the reaction of Schiff base with (phthalic anhydride , maleic anhydride , succinic anhydride , chloroacetyl chloride , thioglycolic acid , sodium azide , glycine , alanine) to get oxazepine derivatives (3 , 4 , 5) , β-lactam derivative (6) , thiazolidine derivative (9) , tetrazole derivative (10) , imidazolidene derivatives(7 , 8) consecutive (scheme 1 ) . II Part two :-The first step includes preparation of Schiff base derivative (compound 11 ) from reaction compound (1) with 3-methoxy-4-hydroxy acetophenone in acid medium, the second step includes the reaction of Schiff base with (phthalic anhydride , maleic anhydride , succinic anhydride , chloroacetyl chloride , thioglycolic acid , sodium azide , glycine , alanine) to get oxazepine derivatives (12 , 13 , 14) , β-lactam derivative (15) , thiazolidine derivative (18) , tetrazole derivative (19) , imidazolidine derivatives(16 , 17) consecutive (scheme 2 )

كلمات الباحثين

البريميدين- مركبات

إشراف وإعداد

الإشراف

شيماء عدنان بهجت

الإعداد

حسين عـواد دلي

الاقتباسات الببليوغرافية