Frequency of Sickle Cell Trait among Relatives of Sickle Cell Anaemia Patients in Al-Gadaref State-Sudan

الموضوعات

طب

الملخص

This study is a descriptive, cross-sectional analytical study aimedto determine the frequency of sickle cell trait among relatives ofsickle cell anaemia patients in Al-Gadaref state –Sudan, duringApril to July 2012. Seventeen families with one hundred andfourteen individuals, with different ethnic descents were involved.56 Males (49.1%), and 58 Females (50.9%), compare to 30healthypersonas a control group. 2.5 ml of venous blood was collected fromeach person in EDTA container with care and adequate safety toensure the reliability of the result, CBC, ESR, sickling test, and Hbelectrophoresis were carried out. The data showed that (67%) ofthe study population were positive and (33%) were negative forsickling test. The results of hemoglobin electrophoresis showedhigh frequency of sickle cell trait (66.7%) amongthe studypopulation followed by HbAA (24.6%), HbSS (5.3%), HbAC (1.8%),and HbSC (1.8%). The highest distribution of sickle cell trait wasfound among Hawsa tribe (36.8%), followed by Fulani (26.3%),Bargo Selehab (15.8%), Hawazma (11.4%) and Fore (9.6%). Mostindividuals in our study their parent coming from a single ethnicdescent(98.24%)whichreflectconsanguineous marriage, thusthehighdegreeofa high risk of augmenting thesickle cell gene. The mean of Hb level, TRBCs, and PCV in patientwithsicklerespectivelycellanemiawere(7.4g/dl),(2.7x106/μl),(22.6%)and in HbSC were (9 g/dl),(3.4x106 μl ),(27%),respectively which are lower than in sickle cell trait that showed(12.5g/dl), (4.6x106/μl), (38.2%) respectively, and HbAC thatshowed (13.5 g/dl),(4.6x106/μl),(41%) respectively which were notsignificantlydifferthancontrol,whoshowed(12.4g/dl),(4.4x106/μl),(37.3%) respectively. The result of MCV, MCHC, andMCH, showed no significant difference between sickle cell trait(82.9fl) ,(32.7g/dl), (27.5pg), respectively, sickle cell anemia thatshowed (86.5fl), (33.3g/dl), (28.2pg), severally, HbSC whichshowed, (79fl), (33mg/dl), (26.6pg), sequentially, HbAC thatshowed (88.6fl), (33.1g/dl), (29pg) , severally, and HbAA thatshowed (83.6fl), (32.3g/dl), (28.1pg), respectively. The totalleukocytes, was significantly elevated in sickle cell anaemia(12.1x103/μl),andHbSCthatshowed(8.5x103/μl),whencompared with sickle cell trait (5.1 x10 3/μl), HbAC that showed,(3.6 x103/μl), and HbAA that showed (4.5 x10 3/μl), no significantdifference between the three group in their value. Platelets countwas higher in HbSS (376 x103/μl) and lower in HbSC (160 x10 3/μl)when compared with HbAS (230 x103/μl), HbAC (235 x103/μl) andHbAA (237 x103/μl) which are not differ in their values. The meanof ESR was higher in HbSS (42.3mm/h) and HbSC (95mm/h) thanin Hb AS (21mm/h), HbAC (8mm/h) and HbAA (11mm/h). Theseresults concluded that sickle cell trait is highly frequent amongthe relatives of sickle cell anaemia patients in study area andcould be capable of spreading the disease further due to highdegree of consanguineous marriage, population unawareness,closed societies and lack of medical counselling, and also provide‫‪an insight sickle cell anaemia was found to be predominant‬‬‫.‪among African immigrant tribes‬‬

روابط وملفات

التعريف والنوع

رقم الوثيقة

0cdb7b07-af6e-4ea8-ae89-710edaa01195

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

33971_1.pdf, 33971_2.pdf, 33971_3.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"لمياء علي الصديق علي","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"مالك حسن ابراهيم مصطفى","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Frequency of Sickle Cell Trait among Relatives of Sickle Cell Anaemia Patients in Al-Gadaref State-Sudan

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

مالك حسن ابراهيم مصطفى

الإعداد

لمياء علي الصديق علي

الاقتباسات الببليوغرافية