Synthesis and biological activity of Some amino acid and Barbituric acid derivatives via Schiff's bases

الموضوعات

علوم بحتة وطبيعية

الملخص

This work involves synthesis and biological activity of some amino and barbituric acid derivatives via shiff bases. This work is divided into six different parts:  Part One:          This part involved the synthesis of different shiff bases [1] by reaction of the aniline with benzaldehyde and its derivatives. Part Two:           This part involved synthesis of phenoxy acetic acid [II] which converted to phenoxy acid chloride [Ш]. Reaction of the latter compound with shiff bases resulted in part one yields acetanilide derivatives Part Three:   This part involved synthesis of amino acid derivatives [3, 4, and 5] by reaction of acetanilide derivatives resulted in part two with different of L-amino acids (Cysteine, Valine, Phenylalanine) as shown in scheme [I].    Part Four:   This part involved synthesis of barbituric acid derivatives [7] by reaction of acetanilide derivatives resulted in part two with guanidine carbonate and diethyl malonate (DEM) as shown in scheme [II].   Part Five:           This part involved characterization of the products above by their melting points, elemental analysis and FTIR spectroscopy listed in table 4, 9, and 11. Part Six:         This part involved the evaluation of antibacterial activity of the products. These activities were determined in vitro using disc diffusion method against two pathogenic strains of bacteria {Pseudomonas aeuroginosa and Staphylococcus aureus}, as shown in table (4-1).

روابط وملفات

التعريف والنوع

رقم الوثيقة

0c732459-2dc7-4a82-999d-35f5ad6738e3

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

14274_1.pdf

بيانات النشر

ترجمة العنوان

تحضير ودراسة الفعالية البايولوجية لبعض مشتقات الاحماض الامينية وحامض الباربيتوريك عن طريق قواعد شيف

ألقاب المؤلفين

[{"name_ar":"Jawad K. Shneine","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"احمد عباس نعمان","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Synthesis and biological activity of Some amino acid and Barbituric acid derivatives via Schiff's bases

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Jawad K. Shneine

الإعداد

احمد عباس نعمان

الاقتباسات الببليوغرافية