Comparative metabolic modeling and analysis of human pathogens

الموضوعات

طب

الملخص

Infectious diseases continue to be major health concerns worldwide. Although major advances have led to accumulation of genomic data about human pathogens, there clearly exists a gap between genome information and studies aiming at identifying potential drug targets. Here, constraint-based modeling (CBM) was deployed to integrate disparate data types with genome-scale metabolic models (GEMs) to advance our understanding of the pathogenesis of infectious agents with respect to identifying and prioritizing drug targets. Specifically, genome-scale metabolic modeling of multiple stages and species of Plasmodium, the causative agent of malaria, was used to prioritize potential drug targets that could be used to simultaneously treat (anti-malarials) and block transmission of the parasite. In addition, species-specific metabolic models were used to guide translation of findings from non-human experimental disease models to human-infecting species. Further, comparative analysis of the essentiality of metabolic genes for V. cholerae, the causative agent of cholera, growth and survival in single and co-infections with other enteric pathogens led to prioritizing conditionally independent essential genes that would be potential drug targets in both single and co-infection scenarios. Taken together, our findings highlight the utility of using genome-scale metabolic models to prioritize druggable targets that would be of broader spectrum against human pathogens.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0c4e7c98-40e8-41d9-a386-284f04a52b5d

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf image

أسماء الملفات

0c4e7c98-40e8-41d9-a386-284f04a52b5d_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Alyaa M. Abdelhalim Mohamed","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Takashi Gojobori","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Comparative metabolic modeling and analysis of human pathogens

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Metabolism Modelling Pathogens Computational Modelling

إشراف وإعداد

الإشراف

Takashi Gojobori

الإعداد

Alyaa M. Abdelhalim Mohamed

الاقتباسات الببليوغرافية