Effects of Antiepileptic Drug (Valporic Acid) on Complete Blood Count Parameters among Patients Attending Eltigain Elmahi Neurological and Psychological Hospital-Khartoum Stata-Sudan

الموضوعات

طب

الملخص

Background Epilepsy, affecting 5-10 per 1000 population, is characterized by the occurrence of at least two unprovoked seizures brought about by abnormal discharge of cortical neurons. The lifetime risk of developing psychiatric disorder with epilepsy is extremely high with such individuals having greater psychiatric co-morbidity when compared to the general population. Valporic acid is a drug used as mood stabilizer and ant convulsion episodes, it has been given indifferent doses prescribed by the physician and most of time as anti-psychological drugs used for life, some side effects occur. So this study aim to focus on the side effectsthatmay present among complete blood count parameters, such as red blood cell count, hemoglobin concentration, total whit blood count and related differential count of Neutrophil, Lymphocyte, and Monocyte. Beside Platelet count and related indices.MethodDescriptive –cross sectional study conducted among 91 psychotic patients with epileptic episodes, set as case group and healthy individuals with no signs of anemia or infection set as control group to compare data with case group. Blood samples were collected in Ethylene Diamin Tetra Acetic Acid (EDTA) for complete blood count CBC, using automatic hematology analyzer Sysmex KX 21.ResultComplete blood count parameters of case group and control group when compared with each other, revealed that significant difference (p value ≤ 0.05) in RBC, Hb and PCV as they were increased among case group than control group (the means of RBCs were 4.78±0.49, 4.44±060 Vand Hb 13.29±1.78g/dl, 12.68±2.14g/dland PCV 42.38± 5.45%, 38.28±6.92%), while platelet count was decreased among case group than control (mean ± SD = 208.09± 100.99, 275.12±101.70).group (p value ≤ 0.05), with difference (p value ≤ 0.05) obtained through independent T test. Dose of drug and duration of taking did not give significant difference (p value ˃ 0.05).Conclusion Anti-epileptic drug, valporic acid has an effect on some of complete blood count parameters, such as platelet count, regardless the duration of medication and gender of patients

روابط وملفات

التعريف والنوع

رقم الوثيقة

0aa08914-29c8-4ab2-bd56-ed7f9733ed08

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2024415_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"حسام علي عثمان","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"نجلاء عبدالحفيظ محمد","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Effects of Antiepileptic Drug (Valporic Acid) on Complete Blood Count Parameters among Patients Attending Eltigain Elmahi Neurological and Psychological Hospital-Khartoum Stata-Sudan

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

حسام علي عثمان

الإعداد

نجلاء عبدالحفيظ محمد

الاقتباسات الببليوغرافية