Study the Effect of Oxidative Stress on Patients with Vitiligo in Anbar Governorate

الموضوعات

طب

الملخص

Oxidative stress is an imbalance between oxidants and antioxidants,Which play an important role in initiation and progression of vitiligo.Vitiligo is an acquired, chronic depigmenting disorder of skin. The diseaseresults from the selective loss of melanocytes. The aim of study is toevaluate effect of oxidative stress, heat and light on treatment of patientswith vitiligo in AL-Anbar governorate.The study has been included 80 blood samples of vitiligo patients (30males and 50 females ) and 40 blood samples from healthy individuals (8males and 32 females ), the date of sampling persists from July 2018 up toJanuary 2019. Many biochemical parameters are performed for all patientsand healthy individuals to know the pathogenesis of Vitiligo in addition toquestioner list which has been filled for each patient .Their ages are divided into different groups: group (A) rangesbetween (10-20) years, group (B) ranges between (21-40) years, group (C)ranges between (41-70) years. Family history of vitiligo was positive in apercentage of (30%) of the patients. The duration of disease ranged between1 month to 20 years . History of seasonal variation of disease was positivein( 60%) patients. Out of these (10%) noticed exacerbation of disease inwinter while (50%) in summer season. Bad emotional state exacerbates ofabout (70%) of vitiligo patients, while the other (30%) does not affect.This study shows that there is no relationship between the occupation,accommodation, most common diet, most common drinks and spiritual sideand vitiligo.Hemoglobin Concentration and Packed cells Volume determination ofpatient's group were significantly lower than those of control group with ( P≤ 0.05 ).The results obtained from this study showed a significant increase inMalondialdehyde (MDA) concentration with ( P ≤ 0.05 ) in vitiligo patientsat comparison with control group and showed that there are no significantdifferences with ( P ≥ 0.05 ) in the concentrations of total bilirubin in vitiligopatients at comparison with control group and showed significant increasein the concentrations of uric acid with (P ≤ 0.05) in vitiligo patients atcomparison with control and showed significantly increase in glutathionconcentration with ( P ≤ 0.05 ) in vitiligo patients at comparison withcontrol group.The statistical analysis for the determination some of vitaminsshowed that there are no significant differences in the concentrations ofvitamin E and C with ( P ≥ 0.05 ) in vitiligo patients at comparison withcontrol group.The statistical analysis for the determination some of trace elementsshowed a significant increase in the concentrations of Zn and Cu with (P≤ 0.05) in vitiligo patients at comparison with control group.This study shows that there is no correlation relationship betweenoxidants MDA and antioxidants ( vitamin C, vitamin E, Zn ). But it shows anegative correlation between MDA and Glutathione (r=-0.447) at significant(p≤0.01) and a positive correlation between MDA and Cu (r=0.409 ) atsignificant (p≤0.01).Lipids profile is determined and the statistical analysis results showthat serum cholesterol, triglycerides, high density lipoprotein cholesterol(HDL-cholesterol), low density lipoprotein cholesterol (LDL-cholesterol)and very low density lipoprotein cholesterol (VLDL-cholesterol) were nosignificant differences than those in control group with ( P ≥ 0.05 ).The results of thyroid hormones determination were in the patient'sgroup T3 and T4 were no significant differences than those in control group( P ≥ 0.05 ).while TSH was significantly higher than those in control group (P ≤ 0.05 ).This study evaluated the effect of Narrow-band ultraviolet B (NB UVB) on the 20 patients ( 12 women and 8 men ) with vitiligo. The responseof 80-90%was given grade excellent and response of 70-80% was givengrade good and response of 60-70% was given grade moderate, whileresponse of 50-60% was given grade mild and response of 40-50% wasgiven grade poor.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0a6f7814-af9c-4076-b593-c85e67c74ca0

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

2306200_1.pdf

بيانات النشر

ترجمة العنوان

دراسة تأثير الإجهاد التأكسدي في المرضى المصابين بالبهاق في محافظة الأنبار

ألقاب المؤلفين

[{"name_ar":"عبد الله صالح حسن","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"وجيه يونس محمد","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"ياسر قاسم حسني","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Study the Effect of Oxidative Stress on Patients with Vitiligo in Anbar Governorate

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Oxidative Stress- Patients with Vitiligo

إشراف وإعداد

الإشراف

عبد الله صالح حسن, وجيه يونس محمد

الإعداد

ياسر قاسم حسني

الاقتباسات الببليوغرافية