Effects of Passive Smoking on Spirometric Values and Plasma Level of Inflammatory Markers in Healthy School Children in Khartoum

الموضوعات

طب

الملخص

Background: Exposure of children to environmental tobacco smoke athome has been linked to many complications including respiratorysymptoms, airway inflammation and impaired lung ventilatory functions;however, factors like housing conditions and genetic predisposition mayinfluence the development of these complications.Objectives: To determine the effects of passive smoking on spirometricvalues and plasma level of inflammatory markers in healthy male schoolchildren.Methods: This is an observational case control study conducted in year2009 among 135 male school-pupils (69 cases and 66 controls), aged 9-14(mean 11.6 ± 1.3) years, selected randomly from three governmentalprimary schools for boys in Khartoum. Information about smoking history,its impact on child’s health and the attitude of parents towards passivesmoking was collected from each pupil and his parents using aquestionnaire. Spirometric measurements were performed using ClementClarke All-flow Spirometer. Plasma CRP, IL4 and TNFα were measuredusing ELISA kits.Results: Fathers were responsible for 67.5% of second-hand smoke athome; mothers were responsible for 2.5% whereas relatives like brothersand uncles were responsible for 30%. The group of cases showed asignificant rise in plasma TNFα and IL4 and a significant reduction in FVCand FEV1 by about (7-8%). The rise in plasma TNFα and IL4 was higher inthose with high degree of tobacco smoke exposure than those with lowexposure, indicating a dose dependent effect. No significant difference wasVfound in frequencies of hospital admissions, surgical operations andrespiratory tract infections during the last year; however, snoring duringsleep was significantly higher among cases (8.2%) than controls (2.2%).The majority of fathers in the study group did not smoke or allow smokingnear their wives during pregnancy (90%).Conclusion & recommendation: Passive smoking has a significantnegative impact on lung function of healthy male school-pupils inKhartoum and a significant dose dependent effect on plasma TNFα andIL4.Educational programs are highly recommended to increase awarenessof parents about the negative impact of passive smoking on child’s health.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0a2c1375-7670-4c0f-b372-e9dbd9d44ddc

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

1638296_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"امل محمود","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"طارق حكيم","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Effects of Passive Smoking on Spirometric Values and Plasma Level of Inflammatory Markers in Healthy School Children in Khartoum

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

امل محمود

الإعداد

طارق حكيم

الاقتباسات الببليوغرافية