Synthesis and Biological Activity Evaluation of Novel Fused Pyrimidine Heterocyclic Compounds

الموضوعات

علوم بحتة وطبيعية

الملخص

A new series of heterocyclic compounds was prepared via the reaction of different substituted hydrazonoyl chlorides 22, 120 and 121 with substituted aminopyrimidines 122-124. The reaction produced in general a mixture of acyclic products 127, 132b, 136, 137, 139a, 139b, 139c and fused heterocyclic rings 129, 133a, 133b, 140a and 140b.The obtained acyclic adducts compounds 127, 132b, 139a, 139b and 139c are produced as a result of direct attack of the pyrimidine amino groups 122-124 at the electrophilic carbon of nitrilimine. In one particular case the acyclic product 136, 137 was obtained as a result of direct attack of the pyrimidine nitrogen at the electrophilic carbon of nitrilimine. The fused imidazopyrimidine derivatives 129, 133a, 133b, 140a and 140b are obtained as a result of the reaction of the dinucleophilic pyrimidine nitrogen and the amino group at the dielectrophilic carbons of nitrilimine.The obtained products were fully characterized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS and HRMS. The structures of compounds 132b and 133b were further confirmed by x-ray.The biological activities of the obtained products were tested and evaluated against Gram-negative and Gram positive microorganisms. The Microbroth Dilution Method was used to evaluate the antibacterial activity and determination of MIC50

روابط وملفات

التعريف والنوع

رقم الوثيقة

09bf5e61-86ad-4dbf-a747-ae712e40bb27

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2102609_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Adel M. Awadallah","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Amani Fawzi Yousef Al-Hallaq","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Omar S. Abu-Tiem ","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Synthesis and Biological Activity Evaluation of Novel Fused Pyrimidine Heterocyclic Compounds

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Adel M. Awadallah, Omar S. Abu-Tiem

الإعداد

Amani Fawzi Yousef Al-Hallaq

الاقتباسات الببليوغرافية