Sero-epidemiological Study of Cytomegalovirus among Sudanese and Libyan Pregnant Women (2018)

الموضوعات

طب

الملخص

Cytomegalovirus (CMV) is a leading healthcare problem associated with stillbirth and congenital abnormalities, determining the Seroprevalence along with the possible risk factors associated with cytomegalovirus infections may play a cornerstone role in preventing its complications. The aim of this study was to determine the seroprevalence and molecular detection of cytomegalovirus among Sudanese and Libyan pregnant women in association with socio-demographic data and maternal risk factors. A total of 445 blood samples were collected from pregnant women with different age groups presented to the outpatient clinic of Obstetrics and Gynecology, 340 from Benghazi- Libya and 110 samples from Wad-Medani. All samples were tested for the presence of both IgG and IgM using Enzyme-Linked Immuno-Sorbent Assay (ELISA), IgM positive samples with ELISA were examined with Polymerase Chain Reaction (PCR) along with other randomly selected negative samples to determine the sensitivity and specificity of ELISA. The Seroprevalence of CMV IgG was 100% in Sudanese and 99.7% in Libyans, while the positive IgM were 0.6% and 6.4% in Libyans and Sudanese respectively. The sensitivity of ELISA compared to PCR was 37.5% while specificity was 100%, Positive Predictive Value was 100%, while Negative Predictive Value was 80.5% with a prevalence of 27.9%. risk analysis showed that both Poverty (OR=8.7, P-value=0.03) and Rural residence (OR= 3.9, P-value= 0.005), were significant risk factors for CMV infections detected by PCR. While illiteracy (OR=1.2, P-value=0.65), and History of abortion (OR=2.6, P-value=0.96) were insignificant for CMV infection. This results concluded that CMV is highly prevalent in Sudan and the risk of either reactivation or primary infection is associated with poor hygiene, further studies should be conducted to estimate the complications in newborns and more diagnostic tools should be involved.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0914cf83-70c5-4eef-abab-09693e1ab4e9

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf image

أسماء الملفات

0914cf83-70c5-4eef-abab-09693e1ab4e9_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":" Ahmad Al-Mustafa Mohammed Shaikh Idris ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Abdullah Al-Mansoury","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Adam Dawoud Abakar Salim ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Rashad Shawgi Babiker Ahmed ","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Sero-epidemiological Study of Cytomegalovirus among Sudanese and Libyan Pregnant Women (2018)

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Ahmad Al-Mustafa Mohammed Shaikh Idris , Abdullah Al-Mansoury, Adam Dawoud Abakar Salim

الإعداد

Rashad Shawgi Babiker Ahmed

الاقتباسات الببليوغرافية