Potency and selectivity of a urokinase activated recombinant anthrax toxin to acute myeloid leukemia (AML) cells

الموضوعات

علوم بحتة وطبيعية

الملخص

Acute myeloid leukemia (AML) is a disorder characterized by uncontrolled mitogen etic activation and proliferation of hematopoietic precursor cells. Up to 30 % of adult patients with AML do not achieve complete remission when treated using chemotherapy. In addition, severe side effects usually limit the efficacy of available therapeutic approaches. As a result, novel tumor-selective therapeutics capable of targeting and eliminating AML blasts while sparing normal cells are urgently needed. In this study, we determine the potency and selectivity of an engineered, urokinase-activated recombinant anthrax fusion toxin (PrAgU2/FP59) on a panel of 9 AML cell lines and on normal progenitor bone marrow blasts. All 9 AML cell lines tested were sensitive to PrAgU2/FP59 while normal progenitor, bone marrow blasts were not, demonstrating the potency and selectivity of this tumor-targeted approach. Cytotoxicity of PrAgU2/FP59 appeared to be non-apoptotic and is dependent on the expression of an active cell surface urokinase plasminogen activator system (uPA/uPAR) system. Targeting the urokinase system, a protease overexpressed on AML cells, appears to be a promising approach for the development of AML-specific therapeutics.

روابط وملفات

الوثيقة في المستودع الخارجي عرض في AskZad

التعريف والنوع

رقم الوثيقة: 08913b19-6202-41e4-8aad-73ec62bb97c4
رقم العقد: 0
نوع الوسائط: Crawler
نوع المحتوى: الرسائل العلمية
صيغة المصدر: رسائل ماجيستير
نوع الملف: pdf text
أسماء الملفات: 2213083_1.pdf

بيانات النشر

ألقاب المؤلفين: [{"name_ar":"Manal El. Darwich","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Ralph Abi Habib ","title_ar":"اشراف","title_en":"Supervision"}]
اللغة: English

المصدر والدورية

اسم المصدر: Potency and selectivity of a urokinase activated recombinant anthrax toxin to acute myeloid leukemia (AML) cells

المحتوى والصفحات

عدد الصفحات: 0
كلمات الباحثين: selectivity of a urokinase

إشراف وإعداد

الإشراف: Ralph Abi Habib
الإعداد: Manal El. Darwich

الاقتباسات الببليوغرافية

APA

Manal El. Darwich و Ralph Abi Habib . (2015). Potency and selectivity of a urokinase activated recombinant anthrax toxin to acute myeloid leukemia (AML) cells. أطروحة(رسائل ماجيستير). مدرسة الآداب والعلوم-الجامعة اللبنانية الأميركية. لبنان.

MLA

Manal El. Darwich و Ralph Abi Habib . Potency and selectivity of a urokinase activated recombinant anthrax toxin to acute myeloid leukemia (AML) cells. 2015. مدرسة الآداب والعلوم-الجامعة اللبنانية الأميركية، رسائل ماجيستير.