تحديد المحتوى الكحولي في بعض شرابات وقطورات الأطفال في السوق المحلية

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

0871db5c-85b3-4006-834b-0a67c3da671d

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1962269_1.pdf

بيانات النشر

ترجمة العنوان

Determination of alchol content in some drops and syrups in local market

ألقاب المؤلفين

[{"name_ar":"رنيم جمال دراج","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"محمد هارون","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

تحديد المحتوى الكحولي في بعض شرابات وقطورات الأطفال في السوق المحلية

المحتوى والصفحات

عدد الصفحات

103

ترجمة الملخص

Syrups and oral drops are widely usedkinds of drug all over the world especially for children and infants due to the facility of using these liquid dosage forms.Drug companies use different solvents to providliquid forms, probably ethanol is one of the most used solvent, therefore;quality control of these medicins is very important to avoid undesirable effects could be occure to children and infants.So, this research was made as a step to make sure that companies had committed to using the allowed percent of ethanol in syrups and drops, and tocompare the real percent of ethanol in syrups and drops with printed percenton the external lable on the container, so we can decide how much are these typs are safefor children and infants.In this research, 20 pharmaceutical dosage forms that are available in local pharmacies in Lattakia had beenstudied; 10 syrups, 8 oral drops and 2 elixirs. These samples were belongedto five drug companies, three batches were studied and three samples of each one.First of all, Some of physical tests were done to control the syrups: (clarity,comparing the real volume of samplewith the printed volumeon the container, labeling, uniformity of mass of delivered doses from multidose container). microbiologicalexaminationtest was done to these nonesterile forms. Qualitative analysis for ethanol and methanolwas performed by colormetric method, then, quantitative analysis for ethanol was performed by gas chromatography and spectrophotometer.The results revealed that all of the samples were clearwithout any precepitations, allof the real volume of the samples wasthe same as the printed volume except four samples, there were some samples werenot well closed so it was replaced with well closed others, all of the samples passedtheuniformity of dosage mass test according to national pharmacopoeia.There were five samples hadnot contain neitherinternal leaflet norpacking container. Two samples of oral dropes hadnot hadthe dropper.The qualitative analysis of methanol showed that all of the samples were free of methanol and that is in accordance to world health organisation registlation. The qualtitative and quantitatve analysis of ethanol revealed that 12 samples had containedethanol, three of them were preinted that they are "free of ethanol", and sevensamples had exceeded the permitted percent according to FDA. The concentration were between ( 0.03-86.92)v\v% using GC.

كلمات الباحثين

Ethanol, GC, Oral drops, Syrups, إيتانول, شرابات دوائية, قطورات فموية, كروماتوغرافيا غازية

إشراف وإعداد

الإشراف

محمد هارون

الإعداد

رنيم جمال دراج

الاقتباسات الببليوغرافية