Assessment the role of survivin and IGF-1 with FOXO1 in patient with Acne Vulgaris in Babylon City

الموضوعات

طب

الملخص

Acne vulgaris (AV) is a chronic cutaneous inflammatory disorder with a complex pathogenesis. It is the eighth most common disease worldwide. Acne vulgaris occurs against the background of seborrhea, a genetically determined condition characterized by increased secretion of chemically altered sebum by the sebaceous glands and the appearance of acne in areas of the skin that are richest in sebaceous glands. A patient with acne usually presents with a history of papules and pustules, most commonly affecting the face, back, chest, and shoulders. Systemic symptoms are often absent, but the patient may describe local symptoms of pain, erythema, or tenderness. Factors in acne vulgaris include insulin growth factor-1, survivin, and the Forkhead transcription factor. The study's objective is to investigate the relationship between serum levels of insulin growth factor-1 (IGF1), survivin, and Forkhead transcription factor (FoxO1) in patients with AV and healthy controls. This study was designed as a case-control study. Forty-five acne patients were involved in this study (20 females and 25 males), in addition to 45 healthy controls (20 females and 25 males), well-matched with the patients in age and gender. Age ranged from 15–30 years, with a mean age of 21.27 ± 3.19 years. Body mass index (BMI) was 22.92 ± 3.12 kg/m². Samples were taken from dermatology clinics at Al-Musayyib General Hospital, Marjan Teaching Hospital, and Imam Al-Sadiq Hospital. The levels of IGF1, survivin, and FoxO1 were measured using the enzyme-linked immunosorbent assay (ELISA) technique. The levels of IGF1, survivin, and FoxO1 were significantly higher than in healthy controls (P ≤ 0.05). The relationship showed a significant association between the level of survivin and gender (P = 0.017), but no significant association was found for IGF-1 and FoxO1. The results showed no significant association between the levels of IGF-1, survivin, and FoxO1 among BMI subgroups. There was no significant difference in IGF-1 and FoxO1 levels (P > 0.05), while a significant association was found between survivin levels and the severity of acne (P < 0.05). There was no significant association between BMI and AV. Positive correlations were found between IGF1 and FoxO1 (P < 0.05), between IGF1 and survivin, and between survivin and FoxO1. The ROC curve test showed a good discriminative value of survivin and FoxO1 between AV patients and controls. Our findings suggest that IGF-1 and survivin could play potential roles in the pathogenesis of acne vulgaris.

روابط وملفات

التعريف والنوع

رقم الوثيقة

083692d2-e00b-46c7-a1d2-647e5d506579

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

995221_1.pdf

بيانات النشر

ترجمة العنوان

تقييم دور السورفايفين ( survivin) وعامل النمو1 الشبيه بالأنسولين (IGF1) وعامل النسخ (FOXO1) لدى مرضى حب الشباب في مدينة بابل

ألقاب المؤلفين

[{"name_ar":"ثناء محمد جودة","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"حمزة محمود حمزة علوان","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"زينة سعيد سلمان","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Assessment the role of survivin and IGF-1 with FOXO1 in patient with Acne Vulgaris in Babylon City

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Acne vulgaris, IGF-1, Survivin, FoxO1, ELISA, Body Mass Index (BMI), Skin inflammation

إشراف وإعداد

الإشراف

ثناء محمد جودة, زينة سعيد سلمان

الإعداد

حمزة محمود حمزة علوان

الاقتباسات الببليوغرافية