تقييم تأثير البيوغليتازون في الوقاية من الاعتلال الكلوي المحدث بالغليسيرول، والمفاقم بالمادة الظليلة إيو هكسول عند جرذان التجربة

الموضوعات

طب

الملخص

خلفية البحث: يعتبر اعتلال الكلية المحدث بالمواد الظليلة من المضاعفات الخطيرة الناجمة عن التصوير الشعاعي اللازم في العديد من المداخلات والإجراءات الاستقصائية والتشخيصية .هدف الدراسة: يهدف هذا البحث إلى تقصي قابلية المادة الظليلة إيوهكسول Iohexolلإحداث تفاقم لوريسي عند جرذان التجربة؛وتقييم دور البيوغليتازون Pioglitazoneفي الوقاية من هذا النموذج من الاعتلال الكلوي، :تعتبر الإصابة الكلوية الحادة من أكثر المضاعفات المهددة للحياة الناتجة عن انحلال الربيدات rhabdomyolysis. يستخدم الغليسيرول glycerolبشكل شائع لإحداث هذا النموذج من الاعتلال الكلوي. الغاية :تقصي دور دواء البيوغليتازون pioglitazoneالواقي للكلية، ومقارنة الفائدة المرجوة من تطبيق الدواء خلال فترتين علاجيتين مختلفيالمدة.المواد والطرائق

روابط وملفات

التعريف والنوع

رقم الوثيقة

06331b3e-768c-4916-afb4-ac858aead6d1

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1962215_1.pdf

بيانات النشر

ترجمة العنوان

Evaluation of Pioglitazone preventive effect in nephropathy induced by Glycerol, and aggravated by Iohexol contrast medium in experimental rats

ألقاب المؤلفين

[{"name_ar":"راما عبدو مصلح","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"شذى اللحام","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

تقييم تأثير البيوغليتازون في الوقاية من الاعتلال الكلوي المحدث بالغليسيرول، والمفاقم بالمادة الظليلة إيو هكسول عند جرذان التجربة

المحتوى والصفحات

عدد الصفحات

205

ترجمة الملخص

Background:Contrast-induced nephropathy (CIN) is still a serious complication of in rats injected with Glycerol; effect on this CIN model in rats, focusing on the role of its antioxidant property in the prevention, and comparing it with that of vitamin E, a well-known antioxidant. Mate rials and me : 42 male Albino Wistar rats were randomly divided into 6 groups (n=7/group): (A): healthy, (B): Glycerol (25%) (10 ml/kg ),(C):Glycerol+ Iohexol(350 mg I/ml) (8.6 ml/kg through a caudal vein), (D)Glycerol+ CM+ PIO (10 ml/kg orally for 4 days), (E)Glycerol+ Iohexol + vitamin E (250 mg/kg orally for 4 days), (F) alone. Serum urea and levels were assess renal function. Reduced (GSH) levels, kidney weight/body weight ratio, alterations were also assessed. Statistical analysis was performed using Prism. Numerical data were evaluated by followed by tests. data were evaluated by Mann–Whitney test and Ficher's exact tests. P values <0.05 were considered significant. : In group (C), serum biomarkers and kidney weight / body weight ratio were significantly increased, and GSH levels significantly decreased, compared with group (B) and (A). The examinations showed significant tubular and injuries. These changes were significantly reversed in rats treated with (D), and with vitamin E (E). In group (D) serum biomarkers and scores were significantly lower than in group (E). But, there was no significant difference in GSH levels between those 2 groups. ion:In conclusion, could injury, and oxidative stress kidneys previously damaged by Glycerol . was able to protect the renal function better than vitamin E. However, their effects on GSH levels were almost similar. .Acute kidney injury is the most life-threatening complication of .Glycerol is commonly used to induce this nephropathy model. aim was to investigate the effect of , and the possible advantage of administering the drug due two different treatment periods.Me .24 male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) Glycerol (50%, 10 ml/kg ), (C) Glycerol + (10 mg/kg orally for 3 days), (D) Glycerol + alterations were also measured. Statistical analysis was performed using Prism. Numerical data were evaluated by (ANOVA) followed by Tukey’s tests. were evaluated by Mann–Whitney test and Ficher's exact tests. P values <0.05 were considered significant. Glycerol-injected rats, serum urea and levels were increased, while GSH levels were decreased compared to group A. The injuries.In -treated rats, the changes in serum biomarkers and in and GSH levels were reversed in groups C and in group D. Kidneys' microscopic examinations showed also some improvements. No statistically significant difference was found between these two preventive groups in most studied features. ion.These results hint that might have effect in this . succeeded to produce this 3 days. Doubling the drug administration produce any significant superior benefit.

كلمات الباحثين

Acute kidney injury, Glycerol, Iohexol, Kidney, Nephropathy, Pioglitazone, Reduced gluthatione, Rhabdomyolysis, احتلال الربيدات, الاصابة الكلوية الحادة, الاعتلال الكلوي, الغلوتاثيون المرجع, الفيتامين e, الكلية, ايوهكسول, بيوغليتازون

إشراف وإعداد

الإشراف

شذى اللحام

الإعداد

راما عبدو مصلح

الاقتباسات الببليوغرافية