Syndrome métabolique d'insulinoresistance et diabète de type 2: Dépistage et recherche de facteurs de risques chez le sujet algérois apparenté ou non à une famille de diabétiques

الموضوعات

علوم بحتة وطبيعية

الملخص

par l'exploration des Le but de cette étude est (i) d'isoler les facteurs de risque du DT2 marqueurs du SMIR ; (ii) Etablir la relation entre ces facteurs de risque et l'hérédité du diabète dans la famille ; (iii) Corréler les marqueurs du SMIR aux hormones de contre-régulation et du stress énergétique (axes corticotrope, thyréotrope et somatotrope) ; et (iv) Influence des règles hygiéno-diététique sur la prévention du diabète devant un terrain de prédisposition. Cette étude nous a dévoilés les mêmes altérations métaboliques et endocriniennes chez les sujets dépistés, qu'ils présentent un ou plusieurs facteurs de risque du SMIR avec ou sans appartenance à une famille de diabétiques. En définitive, il apparaît que la présence du SMIR chez un individu est le principal facteur de risque aggravant l'apparition du DT2, beaucoup plus que le facteur héréditaire

روابط وملفات

التعريف والنوع

رقم الوثيقة

061c96c8-a631-4c54-a0ac-46863575aa5a

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

word

أسماء الملفات

1377710_1.docx, 1377710_2.pdf

بيانات النشر

ترجمة العنوان

المتلازمة الاستقلالية للمقاومة الانسولينية والداء السكرى من النمط الثانى: تشخيص والبحث عن عوامل خطر الإصابة عند الجزائرى ذات صلة أو لا مع عائلة مصابة بالداء السكرى من النمط الثانى - Insulin Resistance Metabolic Syndrome and Type 2 Diabetes: Risk Factor Screening in Algerian Subject With or Without Diabetic Family Related

ألقاب المؤلفين

[{"name_ar":" Ea Koceir","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"أميرة فاطمة بن ناصر","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

French

المصدر والدورية

اسم المصدر

Syndrome métabolique d'insulinoresistance et diabète de type 2: Dépistage et recherche de facteurs de risques chez le sujet algérois apparenté ou non à une famille de diabétiques

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

Introduction: It is described that the type 2 diabetes mellitus (T2DM) pathogenesis is related to several factors. Insulin resistance and metabolic syndrome (IRMS) were the main cause T2DM emergency. In Algeria, the epidemiological study estimates at 7.3% the T2DM prevalence (3 million diabetics). Genetic predisposition may be involved or not environmental factors. Objectives: The aim of this study is (i) to isolate the risk factors for T2DM by IRMS screening; (ii) Establish the relationship between IRMS factors and diabetes heredity; (iii) correlate the IRMS markers to energy stress hormone (corticotrophic, somatotrophic, thyrotrophic axis); (iv) T2DM prevention by dietary and physical activities. Methodology:one hundred no diabetic subjects were included in the study related or not to diabetic family: 43 IRSM subjects with T2DM parental (MSDA),27 IRSM subjects without T2DM parental (MSNA) and30 noIRSM subjects but withT2DM parental (NMSDA).10 healthy volunteers participated in the study.All research was conducted over 12 months at diabetologia department hospital HCA.Diabetes screening was achieved by HGPO testing.Metabolic parameters were determined by spectrophotometry. Insulin, C-peptide, FT4, TSH, ACTH, cortisol and GH by radioimmunoassay. The insulin resistance by HOMA model. The BMI (Body Mass Index) is calculated using the formula Quételet.The T2DM risk is achieved FINDRISK test.Results:The fasting glucose was normal (0.90 g/l) in all three groups, but the HGPO test is disrupted. In MSDA and MSNA groups there is a significant hyperinsulinemia (> 25 μU / ml) and to a lesser extent in group NMSDA (72%, 66% and 57%, respectively).The HOMA model confirms an acute insulin resistance (79%, 75% and 65% increase respectively).Hypertriglyceridemia was observed only in group MSNA (> 1.30 g / l). HDL dyslipidaemia has been identified in women MSDA group (<0.39 g/l). The cortisolemia is abnormally enhanced in three groups (MSDA, MSNA, NMSDA) compared healthy subjects (275, 283 and 294 nM/l vs 179 nM / l respectively).ACTH levels are reduced (24, 20 and 21 pg/ml respectively vs 50 pg/ml in the group control).This cortisol excess does not the adrenal gland secretion, but adipose tissue (literature).Growth Hormone levels are reduced in the 3 groups (0.95, 1.32 and 2.09 mU/l respectively vs 4 mU / l in the group control).The FINDRISK test scores have improved significantly in the three groups after 06 months of dietary and physical activity.Conclusion:Our study seems to confirm that the genetic predisposition to T2DM is not the only factor, but environmental factors identified by IRMS markers. This study has revealed the same metabolic and endocrine alterations in patients screened, they have one or more IRMS risk factors with or without diabetes family. It appears that the IRMS subjects are the main risk factor compounding the onset of T2DM, many more than the hereditary factor.Finally, we have shown that simple dietary guidelines could significantly reduce the risk of developing diabetes in subjects at risk (insulin resistance and non-metabolic

كلمات الباحثين

ACTH, cortisol, Dépistage, Diabète, GH, Hormones thyroïdiennes , Hydrocortisone , insulin resistance, Insulinorésistance, metabolic syndrome, T2DM heredity, T2DM screening, thyroid hormones, الانسولين, الكورتيزول, المتلازمة الاستقلالية للمقاومة الانسولينية, تشخيص الداء السكرى من النمط الثانى, هرمون النمو, هرمونات الغدة الدرقية

إشراف وإعداد

الإشراف

Ea Koceir

الإعداد

أميرة فاطمة بن ناصر

الاقتباسات الببليوغرافية