CHARACTERIZING WITHIN-HOST DIVERSITY IN SHORT-TERM AND VACCINATED COVID-19 PATIENTS

الموضوعات

طب

الملخص

SARS-CoV-2 is the etiological agent of the ongoing COVID-19 pandemic, which has caused massive losses in human lives and strained global health resources. The ongoing vaccination campaigns in many countries have spurred hope that the pandemic's end is in sight. However, the emergence of variants, namely Alpha, Beta, Delta and Omicron, have raised concerns about the effectiveness of these vaccines and other antibody-based therapies. Consequently, the challenge to control the COVID-19 pandemic is beyond deepened as some of SARS-CoV-2 variants, including the recent Omicron variants, have an expanded transmissibility and resistance. The evolution of coronaviruses, like other RNA viruses, begins with the accumulation of mutations within hosts, a few of which may rise in frequency and transmit to other hosts. Here, we aimed to characterize the within-host mutations of SARS-CoV-2 in short-term Delta-infected patients and unvaccinated Omicron-infected individuals. A total of 22 patients of short-term Delta positive (three time points) samples and a total of 421 unvaccinated and vaccinated Omicron-positive samples were sequenced. The within-host diversity was significantly higher among vaccinated individuals in BA.5.2.1 Omicron sub-lineage. Moreover, non-lineage aa mutations were observed in each lineage and sub-lineages, thus accumulation of those mutations in the viral genome among vaccinated population could be lineage or sub-lineage specific. Additionally, a total of fifteen pathogenic non-lineage specific amino acid mutations in S-gene were observed with more than 30% prevalence among vaccinated individuals. In conclusion, it is worthy to further investigate the non-lineage specific mutations, specifically with prevalence of more than 40% and pathogenic mutations, for immune escape analysis.

روابط وملفات

التعريف والنوع

رقم الوثيقة

060239fc-fbd4-41c1-8f91-d8b5ad492dbd

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

798233_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Hadi Mohamad Yassine","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Ummay Salma Abu Habib","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

CHARACTERIZING WITHIN-HOST DIVERSITY IN SHORT-TERM AND VACCINATED COVID-19 PATIENTS

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

SARS-CoV-2 COVID-19 Omicron variants

إشراف وإعداد

الإشراف

Hadi Mohamad Yassine

الإعداد

Ummay Salma Abu Habib

الاقتباسات الببليوغرافية