مقارنة بين الميتروزول والكلوميفين سيترات في تحريض الإباضة

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

05535d13-09d3-4bc9-ae13-201ef2129f62

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1961599_1.pdf

بيانات النشر

ترجمة العنوان

Letrozole versus Clomiphene Citrate in Ovulation Induction

ألقاب المؤلفين

[{"name_ar":"أشرف علبي","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"لبني بسام جورية","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

مقارنة بين الميتروزول والكلوميفين سيترات في تحريض الإباضة

المحتوى والصفحات

عدد الصفحات

105

ترجمة الملخص

Introduction and Aims :Infertility affects one in every seven pairs, Ovulation disorders account for a quarter of these cases, For more than four decades clomiphene citrate has been the first line of treatment for ovulatory disorders .This research aims to compare the effects of letrozole and clomiphene citrate in ovulation in duction in patients with anovulatory infertility. Design: Prospective comparative trial. Materials: The research was conducted at the Infertility Clinic at The Obstetrics and Gynecology University Hospital in Aleppo University among women with anovulatory infertility -second group of WHO classification-between 10/10/2015 and the end of 2016.Methods:The study included 110 women (mean age 29.4 years). 50%received 8mg of letrozole and 50% received 100 mg of clomiphene citrate(both orally from days 5-9 of menstrual cycle).Then the number of follicles, endometrial thickness, ovulation and pregnancy rate were measured in both groups. Statistical analysis was done using SPSS 19 software. P value less than 0.05 was considered significant .Results: The mean age, body mass index, and duration of infertility in both groups were similar. Ovulation oc curred in 81,8% of the cycles in letrozole treated group and in 80% in clomiphene citrate group. The difference was not statistically significant (P=0,808). The mean number of dominant follicles was higher in clomiphene group. The rate of mono follicular development was significantly higher and endometrial response was better (mean endometrial thickness around ovulation and triple line endometrium)in letrozole group. Pregnancy rate was25,5%in letrozole group and9,1%in clomiphene group, which was statistically significant (p=0,023). The difference in side effects and complications was not significant. 81Conclusion and Recommendations: Letrozole and clomiphene citrate have comparable ovulation rate. The effect of letrozole showed a better endometrial response and pregnancy rate compared with clomiphene citrate. This study suggest that letrozole might be an acceptable alternative to clomiphene citrate as first line treatment for anovulatory patients-second group of WHO classification.

إشراف وإعداد

الإشراف

أشرف علبي

الإعداد

لبني بسام جورية

الاقتباسات الببليوغرافية